脑髓康治疗血管性痴呆的临床效果及安全性观察  

Clinical Efficacy and Safety Observation of Naosuikang (脑髓康) in The Treatment of Vascular Dementia

作　　者：关天翔 秦秀德[2] 林松俊[2] 李晋芳[2] 魏佳[2] 虢周科[1] GUAN Tian-xiang;QIN Xiu-de;LIN Song-jun;LI Jin-fang;WE;Adviser： GUO Zbou-ke(The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen Guangdong 518000,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen Guangdong 518000,China.)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518000 [2]深圳市中医院,广东深圳518000

出　　处：《中医药导报》2018年第17期87-89,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(81202653)

摘　　要：目的:观察脑髓康治疗血管性痴呆的疗效及其对肝肾功能的影响。方法:将80例血管性痴呆患者随机分为治疗组和对照组,每组40例。治疗组予脑髓康及尼莫地平模拟片口服;对照组予脑髓康模拟剂及尼莫地平片口服,评估两组治疗前后MoCA、ADL、MMSE积分及肝肾功能指标。结果:治疗组认知功能疗效有效率为70.0%,对照组为25.0%,两组比较,差异有统计学意义(P<0.05);治疗后,两组MMSE积分均高于治疗前,且治疗组高于对照组,差异均有统计学意义(P<0.05);两组ADL积分均低于治疗前,且治疗组低于对照组,差异均有统计学意义(P<0.05);两组MoCA积分均高于治疗前,且治疗组高于对照组,差异均有统计学意义(P<0.05);两组ALT、AST、BUN、Cr水平与治疗前比较,差异均无统计学意义(P>0.05)。结论:脑髓康治疗血管性痴呆有明显疗效,且对人体肝肾功能无明显影响。Objective： To observe the curative effect of Naosuikang on vascular dementia and its effects on liver and kidney function. Methods： A total of 80 patients with vascular dementia were randomly divided into treatment group and control group.The treatment group was given Naosuikang and Nimodipine placebo tablet orally, while the control group was given Naosuikang placebo tablets and Nimodipine tablets orally. The scores of MoCA, ADL, MMSE and liver and kidney function were evaluated before and after treatment in the two groups. The effective rate of cognitive function was 70.0% in the treatment group and 25.0% in the control group. The difference between the two groups was statistically significant（P〈0.05）. After treatment, the MMSE scores of the two groups were higher than before treatment, and the treatment group was higher than the control group, the difference was statistically significant（P〈0.05）. The ADL scores of the two groups were lower than before treatment, and the treatment group was lower than the control group, the difference was statistically significant（P〈0.05）. The MoCA scores of the two groups were higher than those before treatment, and the treatment group was higher than the control group, the difference was statistically significant（P〈0.05）. There were no significant difference in the levels of ALT, AST, BUN and Cr between the two groups before and after treatment（P〈0.05）. Conclusion： Naosuikang has obvious curative effect on vascular dementia, and has no obvious effect on liver and kidney function.

关 键 词：血管性痴呆 脑髓康 健脾补肾 化痰通络 肝肾功能 疗效评估 

分 类 号：R251[医药卫生—中医内科学]