炎症预测和预防动脉粥样硬化性心血管事件的研究进展  

Research Progress of Inflammation as a Method to Predict and Prevent Cardiovascular Events

作　　者：王建旗[1] 史旭波[1] 马长生[1,2] 袁彪[1] WANG Jianqi 1 ,SHI Xubo 1 ,MA Changsheng 1,2 ,YUAN Biao 1(1.Cardiovascular Center of Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China; 2.The Second Department of Cardiology in Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,Chin)

机构地区：[1]首都医科大学附属北京同仁医院心内科,北京100730 [2]首都医科大学附属北京安贞医院心内科,北京100029

出　　处：《心血管病学进展》2018年第5期687-690,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金面上项目(81370237)

摘　　要：炎症与致动脉粥样硬化性脂蛋白的交互作用加速动脉粥样硬化血栓形成的进程,白介素1-肿瘤坏死因子α-白介素6核心信号传递通路的直接抑制因子和上述通路的非直接抑制因子延缓炎症进展。已有随机对照临床研究证实抑制白介素-6核心信号传递通路炎症,降低稳定性冠心病患者再发心血管事件。无论一级预防还是二级预防领域,临床医生应重视心血管事件炎症的预测和评估。高敏C反应蛋白是动脉粥样硬化性心血管事件总体风险评估的有效方法。The interaction between inflammation and atherogenic lipoproteins accelerates atherosclerotic disease progression.The direct or indirect inhibition of the central interleukin 1-tumor necrosis factor α-interleukin 6 signaling pathway can slow down the inflammatory process.The randomized control clinical trials have demonstrated that the direct inhibition of central signaling pathway of interleukin-6 can reduce the cardiac events in patients with stable coronary artery disease.Cardiologists need to pay attention to the evaluation of inflammatory factors in primary and secondary prevention patients.Hypersensitive C-reactive protein is an effective method in estimating the overall risk of cardiovascular event.

关 键 词：炎症 动脉粥样硬化 心血管事件 

分 类 号：R543.5[医药卫生—心血管疾病]