MicroRNA-1与心律失常的关系研究进展  

Research Progress on the Relationship Between MicroRNA-1 and Arrhythmias

作　　者：吴美霞 钟江华[1] WU Meixia,ZHONG Jianghua(Cardiology Department, The Affiliated Haikou Hospital of Central South University Xiangya School of Medicine, Haikou People＇s Hospital, Haikou 570208, Hainan, Chin)

机构地区：[1]中南大学湘雅医学院附属海口医院心血管内科,海南海口570208

出　　处：《心血管病学进展》2018年第5期768-772,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81660057)

摘　　要：MicroRNA是一类单链非编码小分子RNA,其作用是抑制靶信使的转录和翻译,其中microRNA-1是其家族中的一员,主要在心脏中表达。在心肌细胞的多种病理状态下,microRNA-1可以通过转录调节各种离子通道和心肌电活动来参与心律失常的发生。现就microRNA-1与多种心律失常的关系进行综述。MicroRNAs（miRNAs）are a class of small noncoding RNAs that play a role by inhibiting the transcription and translation of target messenger.MicroRNA-1（miR-1）is a member of its family,which is the most abundant miRNA expressed in the heart.In a variety of pathological states of cardiomyocytes,miR-1 can participate in the initiation of arrhythmias by regulating various ion channels and electrical activities of the myocardium.Here,we review the relationship between miR-1 and arrhythmia.

关 键 词：心律失常 MICRORNA-1 离子通道 心肌电活动 

分 类 号：R541.7[医药卫生—心血管疾病]