心房颤动相关的循环微小RNA  

Circulating miRNAs Associated with Atrial Fibrillation

作　　者：余琳 张进[2] 范洁[2] YU Lin 1 ,ZHANG Jin 2 ,FAN Jie 2(1.Kunming University of Science and Technology,Kunming 650500,Yunnan,China; 2.Department of Cardiology,The First Hospital of Yunnan Province,Kunming 650032,Yunnan,Chin)

机构地区：[1]昆明理工大学,云南昆明650550 [2]云南省第一人民医院,云南昆明650032

出　　处：《心血管病学进展》2018年第5期795-798,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金项目(81260038;81360039);云南省心律失常诊治研究中心基金项目(2014NS260;2014NS259)

摘　　要：心房颤动是最常见的临床心律失常疾病之一,其居高不下的死亡率给社会、个人带来沉重负担。微小RNA是小的(约22 nt) RNA,通过结合并抑制特定靶微小RNA的活性而在基因调控网络中发挥重要作用。最近的研究表明微小RNA在血液中以稳定的无细胞形式循环,并且血浆或血清中特定的微小RNA的丰度可以作为心律失常的生物标志物。通过分析2013—2017年期间进行的18项研究微小RNA与心房颤动的关联,可以更好地了解微小RNA与心脏兴奋性以及其他与心房颤动形成有关的主要诱因。现概述关于微小RNA与心房颤动的生物学的基本知识以及目前对该机制的了解,包括关于微小RNA在心房颤动起始和维持中可能的作用所进行微小RNA和心房颤动的实验结果,以及最新研究数据,对未来心房颤动研究方向进行展望。Atrial fibrillation is one of the most common clinical arrhythmia diseases,and its high mortality poses a serious social and personal burden.MicroRNAs（miRNAs）are small（about 22 nt）RNAs that play an important role in gene regulatory networks by binding to and inhibiting the activity of specific target mRNAs.Recent studies have shown that miRNAs circulate in the blood in a stable,cell-free form and that the abundance of specific miRNAs in plasma or serum can serve as biomarkers of cardiac arrhythmias.By analyzing 18 studies conducted between 2013 and 2017 to study the association of miRNAs with atrial fibrillation,one can gain a better understanding of miRNAs and cardiac excitability as well as other major causes of AF formation.In this article,we outline the basics of miRNA and AF biology and our current understanding of the mechanism,including experimental results on miRNA and AF performed on the possible roles of miRNAs in the initiation and maintenance of AF,and recent studies.Finally,the future direction of AF research is prospected.

关 键 词：心房颤动 循环微小RNA 生物标志物 

分 类 号：R541.75[医药卫生—心血管疾病]