主动脉夹层发病机制研究的新进展  

New Research Progress in Pathogenesis of Aortic Dissection

作　　者：侯杨峰 杨文玲 范文静 屈顺林[1,3] HOU Yangfeng 1 ,YANG Wenling 1 ,FAN Wenjing 1,2 ,QU Shunlin 1,3(1.Clinic Department,School of Medicine,University of South China,Hengyang 421001,Hunan,China; 2.The Second Affiliated Hospital of University of South China,Hengyang 421001,Hunan,China; 3.Department of Pathophysiology,Institute of Cardiovascular Disease,Key Laboratory for Atherosclerology of Hunan Province,University of South China,Hengyang 421001,Hunan,Chin)

机构地区：[1]南华大学医学院临床医学系,湖南衡阳421001 [2]南华大学附属第二医院,湖南衡阳421001 [3]南华大学病生教研室心血管病研究所动脉硬化学湖南省重点实验室,湖南衡阳421001

出　　处：《心血管病学进展》2018年第5期847-851,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81670424);湖南省教育厅重点课题(2015JJ2118);湖南省卫计委科研项目(B2016087);国家安全局项目(hunan-0013-2016AQ);南华大学"大学生研究性学习和创新性实验计划"校级立项项目(2017XJXZ031和2017XJYZ048)

摘　　要：主动脉夹层是一种大血管疾病,其突出特点为起病急、进程快、死亡率高。主动脉夹层的发病机制十分复杂,包括免疫炎症、遗传因素、高血压、氧化应激等多个方面。该病的致死原因主要有主动脉夹层动脉瘤破裂至胸、腹腔或者心包腔,进行性纵隔、腹膜后出血以及导致急性心力衰竭或者肾衰竭。现就主动脉夹层多方面的发病机制进行简要综述。Aortic dissection is a macrovascular disease,featured with sudden onset,rapid process and high mortality.The pathogenesis of aortic dissection is complex,including immune inflammation,genetic factors,hypertension,oxidative stress and so on.The cause of death of aortic dissection is the aneurysm rupture to chest cavity,abdominal cavity or pericardial cavity,progressive mediastinal and retroperitoneal hemorrhage,and acute heart failure or renal failure.This article reviews the pathogenesis of aortic dissection in various aspects.

关 键 词：主动脉夹层 炎症 高血压 发病机制 

分 类 号：R543.1[医药卫生—心血管疾病]