内皮细胞微颗粒和心血管疾病的关系  

The Relationship Between Endothelial Microparticles and Cardiovascular Disease

作　　者：王丹宇 王军奎[2] WANG Danyu 1,2 ,WANG Junkui 2(1.Department of Cardiology,Xi an Medical College,Xi an 710032,Shaanxi,China; 2.The First Department of Cardiology,Shaanxi Provincial People s Hospital,Xi an 710068,Shaanxi,Chin)

机构地区：[1]西安医学院,陕西西安710032 [2]陕西省人民医院心血管内一科,陕西西安710068

出　　处：《心血管病学进展》2018年第5期855-858,共4页Advances in Cardiovascular Diseases

摘　　要：内皮细胞微颗粒是多种细胞激活、损伤或凋亡时,细胞膜脱落产生的直径在0. 5~1. 0μm的膜性小囊泡。研究表明内皮细胞微颗粒与内皮功能障碍的关系密切,在介导内皮细胞引起的炎症反应、凝血反应、内皮舒张功能、新生血管生成和内皮细胞凋亡等方面均发挥重要作用。内皮细胞微颗粒与多种心血管疾病密切相关,有可能成为多种心血管疾病不同发展阶段的重要生物标志物,并为临床诊断和治疗心血管疾病提供新靶点。Endothelial microparticles（EMPs）are a variety of small cell vesicles with 0.5~1.0 μm in diameter,which are produced by cell membrane detachment during cell activation,injury or apoptosis.Studies have shown that EMPs are closely related to endothelial dysfunction,and play an important role in the mediation of endothelial cell-induced inflammatory response,coagulation,endothelial function,angiogenesis and endothelial cell apoptosis.EMPs,which are closely related to many cardiovascular diseases,may become important biomarkers in different stages of cardiovascular disease and provide new targets for the clinical diagnosis and treatment of cardiovascular diseases.

关 键 词：内皮细胞微颗粒 心血管疾病 内皮功能障碍 

分 类 号：R54[医药卫生—心血管疾病] Q25[医药卫生—内科学]