受体相互作用蛋白3在心血管疾病中的新进展  

Expression and Possible Function of Receptor-interacting Protein 3 in Cardiovascular Diseases

作　　者：谢田田 刘婷婷 芮涛[1] XIE Tiantian,LIU Tingting,RUI Tao(The Affiliated People s Hospital of Jiangsu University,Zhenjiang 212002,Jiangsu,Chin)

机构地区：[1]江苏大学附属人民医院,江苏镇江212002

出　　处：《心血管病学进展》2018年第5期859-862,共4页Advances in Cardiovascular Diseases

基　　金：中国国家自然科学基金(81370333)

摘　　要：心血管疾病是导致人类死亡的第一大疾病,大多数心血管疾病都伴随着心肌细胞的死亡,最终导致心脏功能的下降。心肌细胞的死亡主要是由于包括坏死及凋亡在内的程序性细胞死亡和不受调控的坏死引起。研究发现受体相互作用蛋白3是研究发现的与细胞程序性坏死密切相关的蛋白激酶,广泛地表达于机体的各个组织,包括脑、肺、脾脏、肝脏、肾脏及心脏在内的组织器官都有着大量的研究,现就受体相互作用蛋白3在心血管疾病中的最新研究进展进行综述。Cardiovascular diseases are the leading cause of human death,and most cardiovascular diseases are accompanied by myocardial cell death that leads to decrease in myocardial contractility.The loss of cardiac myocytes mainly due to programmed cell death including apoptosis and necroptosis or unregulated necrosis.Receptor-interacting protein 3（RIP3） has been found expressed in various organs and is associated with the necroptosis.It has demonstrated that RIP3 is expressed in brain,lung,spleen,liver,kidney and heart.We reviewed the latest research progress of RIP3 in cardiovascular diseases in this article

关 键 词：受体相互作用蛋白3 程序性坏死 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]