乳母与哺乳期婴儿邻苯二甲酸酯类物质暴露水平的相关性  

The correlation between the exposure levels of phthalates in lactating mothers and nursing infants

作　　者：邱竞逸 吴昊 张梅如 王蕾 陈波[2] QIU Jingyi;WU Hao;ZHANG Meiru;WANG Lei;CHEN Bo(Community Development Section of Baiyu Community Health Service Center of Changfeng Community of Putuo District,Shanghai 200063,China;Department of Nutrition and Food Hygiene of Public Health School of Fudan University,Shanghai 200032,China;Community Development Section of Baoshan Community Health Service Center of Jingan District,Shanghai 200071,China)

机构地区：[1]上海市普陀区长风街道白玉社区卫生服务中心社区科,上海200063 [2]复旦大学公共卫生学院营养与食品卫生教研室,上海200032 [3]上海市静安区宝山街道社区卫生服务中心社区科,上海200071

出　　处：《上海医药》2018年第18期58-62,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：上海市普陀区科学技术委员会2015年普陀区科技发展基金(卫生项目)(普科委【2015】27号;普通项目18号)

摘　　要：目的 :利用乳母与婴儿尿中邻苯二甲酸酯代谢物研究邻苯二甲酸酯类物质(phthalates,PEs)的暴露水平,探讨乳母与婴儿邻苯二甲酸暴露水平之间的相关性。方法 :采用横断面调查方法对154对婴儿和及其乳母进行问卷调查并采集随机尿样;采用高效液相色谱-串联质谱法检测婴儿及其乳母尿中10种PEs浓度;分析尿肌酐校正后的PEs相关性。结果 :乳母与婴儿尿液中PEs浓度相关性多集中在乳母尿液中的MMP、MEP、MiBP、MnBP、MEHP和MBzP与婴儿尿液中的MEP、MiBP、MnBP、MBzP、LMWP、HMWP和Σphthalate之间(P <0.05),相关系数r在0.176~0.501之间。结论 :上海市三个区(县)乳母和婴儿的PEs暴露水平较高,且婴儿暴露水平高于乳母,婴儿PEs的暴露与其乳母存在显著的相关性,这表明有必要控制母亲对PEs的接触。Objective： To use phthalate metabolites in the urine of lactating mothers and infants to study the exposure levels of phthalates（PEs） to explore the correlation of the level exposure of phthalates between them. Methods： A questionnaire was conducted in 154 infants and their lactating mothers and random urine samples were collected by a cross-sectional survey; high performance liquid chromatography-tandem mass spectrometry（HPLC） was used to detect 10 PEs concentrations in the urine of infants and their lactating mothers to analyze the correlation of PEs after creatinine correction. Results： The correlation between PEs concentrations in the urine of lactating mothers and infants was mainly concentrated in MMP, MEP, MiBP, MnBP and MEHP and MBzP in the urine of mothers and MEP, MiBP, MnBP, MBzP, LMWP, HMWP and Σphthalate in the urine of infants（P〈0.05）, and the correlation coefcient r was between 0.176~0.501. Conclusion： The PEs exposure level of lactating mothers and infants in three districts（counties） of Shanghai is relatively high, and the exposure level of the infants is higher than that of the lactating mothers, and there is a signifcant correlation between the exposure of infant PEs and their lactating mothers, which indicates that it is necessary to control the mother’s contact with PEs.

关 键 词：邻苯二甲酸酯类物质 哺乳期暴露 乳母 婴儿 相关性 

分 类 号：R174.4[医药卫生—妇幼卫生保健]