益气养阴通络散结方治疗早期糖尿病性心脏病的临床研究  

Clinical Study on Yiqi Yangyin Tongluo Sanjie Formula in the Treatment of Diabetic Myocardial Disease

作　　者：吴淑馨[1] 孙宏峰[1] 龙泓竹[2] 田文杨 张力[1] 白颖[1] 丛佳林 孙露[1] 杨晓晖[1] Wu Shuxin;Sun Hongfeng;Long Hongzhu;Tian Wenyang;Zhang Li;Bai Ying;Cong Jialin;Sun Lu;Yang Xiaohui(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学东方医院,北京100078 [2]中日友好医院,北京100029

出　　处：《世界中医药》2018年第7期1658-1661,1665,共5页World Chinese Medicine

基　　金：北京中医药大学自主选题项目:中青年教师类(2015-JYB-JSMS126)

摘　　要：目的:观察益气养阴通络散结中药方对早期糖尿病性心脏病的疗效。方法:选取2012年10月至2014年1月北京中医药大学东方医院收治的符合诊断标准的早期糖尿病性心脏病辨证为气阴两虚夹瘀证者共63例,随机分为对照组和观察组,对照组的基础治疗包括患者教育、饮食治疗、运动治疗及控制血糖等。观察组在对照组的基础上给予益气养阴通络散结方,疗程共8周,比较2组患者的超声心动改善情况、中医症候各项评分及症状体征总积分。结果:益气养阴通络散结方观察组改善了A/E、AO、LVDs、LVDd、LPW、EF等超声心动指标(P<0.05,P<0.01),改善了胸闷、胸痛、疲倦乏力、口渴喜饮、肢体麻木等症候(P<0.05,P<0.01),观察组中医症状体征总积分显著低于对照组(16.55 vs 23.44)。结论:益气养阴通络散结方改善了糖尿病患者的左心室舒张功能,改善了中医临床症候,对糖尿病患者的早期心脏病变有一定的保护作用。Objective： To investigate the effects of Yiqi Yangyin Tongluo Sanjie formula（ YQYYTLSJF） on patients with early diabetic heart disease.Methods： Sixty three patients with diabetic heart disease were randomly divided into treatment group and control group.The patients of the treatment group took orally YQYYTLSJF and the control group took conventional treatment for eight weeks.The ultrasonic cardiac index,the scores of TCM syndromes and the total points of symptoms of both groups were compared after the experiment.Results： Compared with the control group,the YQYYTLSJF group improved the ultrasonic cardiac index of A/E,AO,LVDs,LVDd,LPW and EF（ P〈0.05,P〈0.01）,relieved the symptoms of chest tightness,chest pain,fatigue,thirst and numbness（ P〈0.05） after eight weeks treatment.The YQYYTLSJF group effectively reduced the score of TCM symptom（ 16.55 vs 23.44）.Conclusion： YQYYTLSJF can improve the left ventricular diastolic function,improve the clinical symptoms of TCM,and protect hearts of diabetic patients.

关 键 词：早期糖尿病心脏病 益气养阴通络散结 气阴两虚夹瘀 

分 类 号：R256[医药卫生—中医内科学] R285.6[医药卫生—中医学]