我国成人隐匿性自身免疫糖尿病的发病与流行  

Latent autoimmune diabetes in adults in China:clinical features and epidemiology

作　　者：彭亚妮[1] 李霞[1] 周智广[1] PENG YaNi;LI Xia;ZHOU ZhiGuang(National Clinical Research Center for Metabolic Diseases,Key Laboratory of Diabetes Immunology,Ministry of Education,Diabetes Center of Central South University,Institute of Metabolism and Endocrinology,The Second Xiangya Hospital of Central South University,Changsha 410011 China)

机构地区：[1]中南大学湘雅二医院代谢内分泌科中南大学糖尿病中心糖尿病免疫学教育部重点实验室国家代谢性疾病临床医学研究中心,长沙410011

出　　处：《中国科学：生命科学》2018年第8期847-854,共8页Scientia Sinica(Vitae)

摘　　要：成人隐匿性自身免疫糖尿病(LADA)是一类成年起病且进展相对缓慢的自身免疫糖尿病,在与2型糖尿病相似的临床表现之下,有着类似经典1型糖尿病自身免疫破坏所致的胰岛功能持续减退.通过增强对LADA临床表现和免疫特性的了解,可以更清楚地认识这一类型的糖尿病,避免和减少误诊、漏诊.欧美及亚洲邻国关于LADA的流行病学调查已在一定程度上揭示了LADA患者临床特征及疾病进展的规律,而我国以LADA China研究为代表的全国多中心研究更为中国人群LADA的发病情况与流行特点提供了证据.Latent autoimmune diabetes in adults（LADA） is a type of adult-onset autoimmune diabetes with the autoimmune attack against islet beta cells similar to classic type 1 diabetes（T1 DM） while manifesting as the slow progressing T2DM. Understanding more about the clinical and immunological features of LADA could help in avoiding misdiagnosis. Epidemiology studies of LADA in Europe, North America, and other Asia countries have revealed the clinical characteristics and disease progression of LADA to a certain extent. The LADA China Study and other studies in China provided further evidence for the prevalence of LADA in the Chinese population.

关 键 词：LADA 胰岛自身抗体 流行病学 中国人群 

分 类 号：R587.1[医药卫生—内分泌]