我国糖尿病患者合并肾病的现状  

Kidney disease incidence in patients with diabetes mellitus in China

作　　者：曹东维[1] 朱大龙[2] CAO DongWei;ZHU DaLong(Department of Nephrology,Affiliated Drum Tower Hospital Medical School of Nanjing University,Drum Tower Clinical Medical College of Nanjing Medical University,Nanjing 210008,China;Department of Endocrinology,Affiliated Drum Tower Hospital Medical School of Nanjing University,Drum Tower Clinical Medical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院南京大学医学院附属鼓楼医院肾内科,南京210008 [2]南京医科大学鼓楼临床医学院南京大学医学院附属鼓楼医院内分泌科,南京210008

出　　处：《中国科学：生命科学》2018年第8期866-871,共6页Scientia Sinica(Vitae)

基　　金：南京市医学科技发展项目(批准号:YKK15057;YKK16097);国家自然科学基金(批准号:81473684);南京市科技发展计划(批准号:201605019);江苏省重点研发计划(批准号:BE2015604)资助

摘　　要：糖尿病肾病(DKD)是糖尿病最主要的微血管并发症,是全球终末期肾病(ESRD)的主因.随着我国经济迅猛发展,糖尿病患病率呈显著上升趋势,我国DKD已逐渐成为ESRD的主要原因,且2型糖尿病患者合并慢性肾脏病(CKD)患病率高,糖尿病作为ESRD病因的血透患者的生存率低.高尿酸血症是DKD的独立危险因素,DKD和糖尿病合并CKD的治疗除既往的控制血糖、血压、减少尿白蛋白及治疗并发症外,降尿酸逐渐被关注.糖尿病患病率的迅速上升对于我国CKD的流行病学影响如何,以及如何早期诊断、预防与延缓DKD和糖尿病合并CKD的发生发展均是需要急切解决的问题.基于此,本文就我国糖尿病合并肾病情况相关流行病学及诊治研究作简要综述.Diabetic kidney diseases（DKDs） are the primary diabetic microvascular complications and the main causes of end-stage renal disease（ESRD） worldwide. In China, the prevalence of diabetes has increased alongside the fast economic development. DKD has gradually become the chief cause of ESRD, and the prevalence of patients with type 2 diabetes mellitus and chronic kidney disease（CKD） is high. Patients with DKD have worse survival than those with comorbid diabetes on chronic hemodialysis. Hyperuricemia is an independent risk factor for DKD. The treatments of DKD and diabetes with comorbid CKD include the usual blood glucose and pressure controls, urinary albumin reduction, and treatment of complications. Currently, lowering uric acid is gradually gaining focus as a treatment. How is the rapid rise in the prevalence of diabetes affecting that of CKD in China？ The problems of how to ensure early diagnosis, prevention, and delay of the development of DKD and diabetes with comorbid CKD require solutions. In this study,we summarize the epidemiology, diagnosis, and treatment of DKD and those of diabetes with comorbid CKD in China.

关 键 词：糖尿病 慢性肾脏病 DKD 流行病学 高尿酸血症 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]