血清RBP4、hs-CRP水平检测对孕早期糖尿病的诊断价值  

Diagnostic value of serum RBP4 and hs-CRP in early pregnancy diabetes

作　　者：卢超[1] 任卫华[1] LU Chao;REN Weihua(Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang Henan 471009,Henan)

机构地区：[1]郑州大学洛阳附属中心医院,河南洛阳471009

出　　处：《中国民康医学》2018年第18期17-19,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清视黄醇结合蛋白4(RBP4)、高敏C反应蛋白(hs-CRP)水平检测对孕早期糖尿病的诊断价值。方法:选取2016年12月至2018年12月郑州大学洛阳附属中心医院收治的56例孕早期糖尿病患者为研究组,另选取同期56例健康体检的正常妊娠孕妇为对照组。(1)比较两组血清hs-CRP及RBP4水平;(2)比较两组血清hs-CRP及RBP4水平单独与联合诊断孕早期糖尿病的特异度、敏感度及准确度。结果:研究组血清hs-CRP及RBP4水平均明显高于对照组,差异有统计学意义(P<0.05);联合诊断敏感度、准确度均明显高于hs-CRP单独诊断,差异均有统计学意义(P<0.05);联合诊断敏感度高于RBP4单独诊断,差异有统计学意义(P<0.05);联合诊断准确度、特异度与RBP4单独诊断比较,差异无统计学意义(P>0.05);联合诊断特异度与hs-CRP单独诊断比较,差异无统计学意义(P>0.05)。结论:孕早期糖尿病患者血清RBP4、hs-CRP表达水平显著增高;二者联合检测可明显提高孕早期糖尿病诊断的敏感度与准确度,降低漏诊风险,为临床及早确定有针对性的干预方案提供一定客观依据。Objective： To analyze diagnostic value of serum retinol binding protein 4 （RBP4） and hypersensitive C-reactive protein （hs-CRP） levels in early gestational diabetes. Methods： 56 patients with early gestational diabetes, who were admitted to Luoyang central hospital affiliated to Zhengzhou university from December 2016 to February 2018, were selected as the study group, and another 56 healthy pregnant women, who had physical examination during the same period, were selected as the control group. （1） The serum hs-crp and RBP4 levels were compared between the two groups. （2） The specificities, sensitivities and accuracies of single hs-CRP or RBP4 detection and combined detection of hs-CRP and RBP4 in the diagnosis of diabetes were compared. Results： The serum levels of hs-CRP and RBP4 in the study group were significantly higher than those in the control group, and the differences were statistically significant （ P 〈0.05）. The sensitivity and accuracy of combined diagnosis were significantly higher than that of hs-CRP alone, and the difference was statistically significant （ P 〈0.05）. The sensitivity of combined diagnosis was higher than that of RBP4 alone, and the difference was statistically significant （ P 〈0.05）. There were no significant differences in the accuracy and specificity between the combined diagnosis and RBP4 alone （ P 〉0.05）. There was no significant difference in the specificity between the combined diagnosis and hs-CRP alone （ P 〉0.05）. Conclusions： The expression levels of serum RBP4 and hs-CRP in the patients with gestational diabetes are significantly increased. Their combined detection can significantly improve the diagnosis sensitivity and accuracy, reduce the risk of missed diagnosis, and provide an objective reference for clinically identifying targeted interventions.

关 键 词：RBP4 HS-CRP 孕早期糖尿病 诊断准确率 

分 类 号：R714.147[医药卫生—妇产科学]