门奇断流术治疗对肝硬化门脉高压患者肝功能影响  

Effect of devascularization on liver function in patients with cirrhosis and portal hypertension

作　　者：秦胜利 QIN Sheng-li(Department of General Surgery,Xinyang Central Hospital,Henan 464000,China)

机构地区：[1]信阳市中心医院普外科,河南464000

出　　处：《中国临床新医学》2018年第9期916-919,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

摘　　要：目的分析门奇断流术治疗对肝硬化门脉高压患者肝功能影响。方法选取肝硬化门脉高压患者82例,按不同的治疗方式分为两组,各41例。对照组实施双介入栓塞术治疗,研究组采用门奇断流术治疗,对比两组患者治疗前及治疗后1个月血常规变化情况、肝功能变化情况及治疗情况。结果治疗前,两组患者血常规及肝功能差异无统计学意义(P> 0. 05);治疗后1个月,研究组血小板计数、白细胞计数较对照组增多,差异有统计学意义(P <0. 05)。治疗后研究组凝血酶原活动度及白蛋白分别为(79. 4±5. 2)%、(28. 6±2. 1) g/L,较对照组的(69. 3±6. 0)%、(24. 0±2. 8) g/L提高,差异有统计学意义(P <0. 05);研究组红细胞计数,总胆红素及丙氨酸转氨酶与对照组相比,差异无统计学意义(P> 0. 05);研究组复发率(7. 3%)较对照组(26. 8%)降低,差异有统计学意义(P <0. 05);研究组病死率(4. 9%)与对照组(9. 8%)比较,差异无统计学意义(P> 0. 05)。结论对肝硬化门脉高压患者实施门奇断流术治疗,有助于改善血细胞及肝功能水平,降低复发率,改善预后,具有临床应用价值。Objective To study the effect of devascularization on liver function in patients with cirrhosis and portal hypertension. Methods 82 patients with cirrhosis and portal hypertension were selected and divided into two groups according to different treatment methods, with 41 cases in each group. The control group received double interventional embolization, and the study group received devascularization therapy. The changes of blood routine examination and liver function, and treatment results were compared between the two groups before and 1 month after treatment. Results There were no significant differences between the two groups in blood routine and liver function before treatment（P〉0.05）. One month after treatment, the platelet count and white blood cell count of the study group were significantly higher than those of the control group（P〈0.05）. The prothrombin activity and albumin content in the study group were significantly higher than those in the control group[（79.4±5.2）% vs （69.3±6.0）%, （28.6±2.1）g/L vs （24.0±2.8）g/L]（P〈0.05）. There were no significant differences between the two groups in red blood cell count, total bilirubin and alanine aminotransferase content（P〉0.05）. The recurrence rate of the study group（7.3%） was significantly lower than that of the control group（26.8%）（P〈0.05）. There was no significant difference in the mortality rate between the study group（4.9%） and the control group（9.8%）（P〉0.05）. Conclusion Devascularization can help to improve the levels of blood cells and liver function, reduce the recurrence rate and improve the prognosis in patients with liver cirrhosis and portal hypertension.

关 键 词：门脉断流术 脾脏切除术 肝硬化门脉高压 肝功能 

分 类 号：R657.34[医药卫生—外科学]