心达康联合阿托伐他汀用于冠心病不稳定型心绞痛的疗效及对血清NO、ET-1、VEGF的影响  

Effect of Xindakang combined with atorvastatin on unstable angina pectoris of coronary heart disease and it's influence on serum NO, ET-1 and VEGF

作　　者：黄咏歌 HUANG Yongge(Luogang District Hospital of Traditional Chinese Medicine of Guangzhou City,Guangzhou 510530,China)

机构地区：[1]广州市萝岗区中医医院,广东广州510530

出　　处：《中国医药科学》2018年第16期160-163,共4页China Medicine And Pharmacy

摘　　要：目的探讨心达康联合阿托伐他汀用于冠心病不稳定型心绞痛的疗效及对血清一氧化氮(NO)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)的影响。方法选择我院2015年6月~2016年6月收治的106例冠心病不稳定型心绞痛患者,按抽签法分为对照组和研究组各53例,对照组予以阿托伐他汀治疗,研究组在此基础上加用心达康治疗,比较两组临床疗效、硝酸甘油用量、心绞痛频率以及血清NO、ET-1、VEGF水平和安全性。结果研究组治疗总有效率显著高于对照组,差异有统计学意义(P <0.05);研究组患者治疗后硝酸甘油用量与心绞痛频率均显著低于对照组,差异有统计学意义(P <0.05);研究组治疗后血清NO、ET-1、VEGF水平均显著优于对照组,差异有统计学意义(P <0.05);用药期间两组均未见明显不良反应。结论心达康联合阿托伐他汀治疗冠心病不稳定型心绞痛疗效显著,能够提高血清NO、VEGF水平,抑制ET-1表达。Objective To explore the clinical effects Xindakang combined with atorvastatin on unstable angina peetoris of eoronary heart disease and it＇ s influenee on serum nitrie oxide（NO）, endothelin-1（ET-1）, vaseular endothelial growth faetor（VE（;F）. Methods One hundred and six patients with unstable angina peetoris of coronary heart disease who treated in our hospital from June 2015 to June 2016 were selected, and were divided into control group and research group according to the lottery method, each group with 53 eases. The control group was treated with atorvastatin, and the research group was treated with Xindakang based on the control group. Clinical efficacy, glyeeryl trinitrate dosage, angina frequency, serum NO, ET-1, VE（;F, and safety between two group were compared. Results The total effective rate of the research group was significantly higher than that of control group, the difference was statistically signifieant（P 〈 0.05）. After treatment, the glyeeryl trinitrate dosage and angina frequency of the research group were significantly lower than those of control group, the difference was statistically signifieant（P 〈 0.05）. The levels of serum NO, ET-1 and VEGF of the research group were significantly better than those of the control group after treatment（P 〈 0.05）. No obvious adverse reactions were observed in the two groups during medication. Conclusion Xindakang combined with atorvastatin is effective in the treatment of unstable angina peetoris of coronary heart disease. It can increase the level of serum NO and VE（;F and inhibit the expression of ET-1.

关 键 词：冠心病不稳定型心绞痛 心达康 阿托伐他汀 硝酸甘油 细胞因子 

分 类 号：R541.4[医药卫生—心血管疾病]