CT定量腹部内脏脂肪组织技术优化  

Optimization of quantifying visceral adipose tissue with CT

作　　者：苏大同[1] 王敏[1] 于铁链[1] SU Da-tong;WANG Min;YU Tie-lian(Department of Radiology,General Hospital,Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院放射科,天津300052

出　　处：《天津医科大学学报》2018年第5期457-460,共4页Journal of Tianjin Medical University

摘　　要：目的:评估CT测量腹部内脏脂肪(VAT)与血脂的相关性,优化CT定量VAT技术。方法:使用CT阈值分割法测量61例受检者胸12/腰1、腰1/2、腰2/3、腰3/4、腰4/5、腰5/骶1共6个椎间隙水平的单层面腹部VAT体积,并计算内脏脂肪组织指数(VATI,VAT/身高2)。对VAT、VATI与血脂各项指标进行Pearson线性相关分析,运用ROC曲线分析VAT、VATI预测高脂血症的诊断效能,确定CT定量VAT的最佳技术。结果:61例受检者中高脂血症占比55.7%,VAT、VATI与高脂血症存在明显相关性,腰3/4椎间隙水平相关性最高(P均<0.05)。ROC曲线分析显示VATI较VAT诊断效能稍高(AUC:0.83 vs 0.826),二者的临界值分别为64.80 cm^3/m^2及184.78 cm^3。结论:腰3/4水平是CT定量VAT的最佳单层面。VATI比VAT对预测高脂血症具有稍高的诊断效能。Objective： To optimize quantifying visceral adipose tissue （VAT） and to evaluate the correlation between VATs and hyperlipidemia. Methods： Sixty-one cases with blood lipids undergoing abdominal CT scan were selected in this study. VAT was quantified on CT image using threshold-based analysis with GE workstation on the levels of interspaces between thoracic vertebrae 12/lumbar 1, lumbar1/2, 2/3, 3/4, 4/5 and lumbar 5/sacral 1, respectively.VAT index （VATI） was transformed by VAT divided by the square of the stature. The pearsoncorrelation analysis was performed to evaluate the correlation between the VAT/VATs and hyperlipidemia. The diagnostic value and the cut-off value of VAT/VATs on predicting hyperlipidemia were assessed using ROC curve analysis. Results： Of 61 cases, 55.7% suffered from hyperlipidemia. Significant correlations were detected between VAT / VATI and hyperlipidemia. The best correlation was found on the level of lumbar 3/4 （all P values〈 0.05）. The ROC curve analysis showed the VATS had a slightly better performance compared with VAT （AUC： 0.83 vs 0.826）, and the cut-off value was 64.80 cm3/m2 for VATS and 184.78 cm3 for VAT. Conclusion： The VAT measured on the level of lumbar 3/4 is recommended for the best slice owing to its significant correlation with hyperlipidemia. The VATI has a slightly better predictive performance than VAT.

关 键 词：内脏脂肪组织:高脂血症:计算机体层摄影:最佳层面:临界值 

分 类 号：R445[医药卫生—影像医学与核医学]