Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots  

作　　者：Lingjie Meng Qinglan Guo Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

出　　处：《Chinese Chemical Letters》2018年第8期1257-1260,共4页中国化学快报（英文版）

基　　金：Financial support from the National Natural Science Foundation of China (Nos. 81373287, 81630094, and 30825044) is acknowledged

摘　　要：A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism（CD） data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated.A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism（CD） data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated.

关 键 词：Isatis indigotica CRUCIFERAE Ban lan gen Indole-lignan conjugate Isatindolignanoside A Antiviral activity 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]