Organocatalytic cascade 1,6-conjugate addition/annulation/tautomerization of functionalized para-quinone methides： Access to chiral 2-amino-4-aryl-4H-chromenes  

作　　者：Cong Duan Ling Ye Wenqin Xu Xinying Li Feng Chen Zhigang Zhao Xuefeng Li 

机构地区：[1]College of Chemistry and Environment Protection Engineering, Southwest Minzu University, Chengdu 610041, China [2]Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, Chengdu 610031, China

出　　处：《Chinese Chemical Letters》2018年第8期1273-1276,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21402163);the Fundamental Research Funds for the Central Universities of Southwest Minzu University (No. 2016NGJPY02);the Graduate Innovation Project of Southwest Minzu University (No. CX2017SZ016);the Undergraduate Innovation Project of Southwest Minzu University (No. S201610656092)

摘　　要：A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields（88%-99%） and excellent enantiopurities（86%-99% ee）. The functionalized para-Quinone methides（p-OMs） could be facilely obtained.A novel organocatalytic cascade process initiated by 1,6-conjugated addition has been successfully developed. A range of pharmaceutically active 2-amino-4-aryl-4H-chromenes were readily obtained in high yields（88%-99%） and excellent enantiopurities（86%-99% ee）. The functionalized para-Quinone methides（p-OMs） could be facilely obtained.

关 键 词：para-Quinone methides 2-Amino-4-aryl-4H-chromene Domino reaction 1 6-Conjugated addition Enantioselective 

分 类 号：O625.6[理学—有机化学]