Photo-responsive nanoparticles for β-lapachone delivery in vitro  

作　　者：Huibo Li Changmai Chen Qin An Guoyan Huo Mingtao Run 

机构地区：[1]School of Chemistry and Environmental Science, Hebei University [2]State Key Laboratory of Natural & Biomimetic drugs, The School of Pharmaceutical Sciences, Peking University

出　　处：《Chinese Chemical Letters》2018年第9期1347-1349,共3页中国化学快报（英文版）

基　　金：supported by SKL Professor Tang’ Laboratory

摘　　要：Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly （ethylene glycol） dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.Drug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly （ethylene glycol） dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.

关 键 词：PHOTORESPONSIVE NANOPARTICLE β-Lapachone UV irradiation Treatment of cancer 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]