埃普利诺菌素纳米乳的制备与表征  

Preparation and characterization of eprinomectin nanoemulsion

作　　者：芮亚培 邱刚 李家奎 孙红武[2] RUI Ya-pei;QIU Gang;Li Jia-kui;Sun Hong-wu(College of Animal Science,Xizang Agri culture and Animal Husbandry College,Linzhi,Tibet 860000,China;Department of Microbiol-ogy and Biochemical Pharmacy,College of Pharmacy,Third Military Medical University,Chongqing 400038,China;College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,China)

机构地区：[1]西藏农牧学院动物科学学院,西藏林芝860000 [2]第三军医大学药学院微生物及生化药学教研室,重庆400038 [3]华中农业大学动物医学院,湖北武汉430070

出　　处：《中国兽医学报》2018年第9期1775-1778,共4页Chinese Journal of Veterinary Science

基　　金：西藏自治区科技厅与西藏农牧学院联合基金(2014ZR-NQ-4)

摘　　要：采用伪三元相图法制备埃普利诺菌素纳米乳并考察其微观形态及粒径分布。结果显示：由EL-35,乙酸乙酯、1,2-丙二醇为主要组分制备的埃普利诺菌素纳米乳澄清透明,透射电镜下液滴均呈球形。经激光粒度分析仪检测,其平均粒径为18.85nm,多分散系数（PDI）为0.1,其分散度良好。该纳米乳以15 000r/min速度离心30min和留样2,4,6个月后,外观基本无变化。结果表明,所制备埃普利诺菌素纳米乳符合纳米乳的性质和特征。Eprinomectin nanoemulsion was preparated by pseudoternary phase diagrams method and detected its morphology and particle size distribution.The results showed that eprinomectin nanoemulsion which consisited of EL-35,1,2-propylene glycol and ethyl acetate was a kind of clear solution and presented as small spherical drops under transmission electron microscope.The results of the laser particle size analyzer showed that the average particle size of eprinomectin nanoemulsion was 18.85 nm and PDI was 0.1,that displayed the dispersion was good.The appearence of eprinomectin nanoemulsion had no change by high speed centrifugation and retention.All results showed that the eprinomectin nanoemulsions conformed to the nature and characteristics of nano emulsion.

关 键 词：埃普利诺菌素 纳米乳 伪三元相图 

分 类 号：S859[农业科学—临床兽医学]