血清同型半胱氨酸、谷氨酰转移酶与冠心病及冠脉狭窄程度的相关性  

Correlation between homocysteinemia, glutamyltransferase and coronary heart disease and the degree of coronary artery stenosis

作　　者：陈敏 杨林飞[1] 孙桂兰[1] 高玉[1] CHEN Min;YA NG Linfei;SUN Guilan;GAO Yu(Department of Cardiology,the Second People＇s Hospital of Hefei,Anhui Province,Hefei 230000,China)

机构地区：[1]合肥市第二人民医院心血管内科,安徽合肥230000

出　　处：《中国医药导报》2018年第26期50-53,共4页China Medical Herald

摘　　要：目的探讨生化指标血清同型半胱氨酸(HCY)、谷氨酰转移酶(GGT)与冠心病的相关性及诊断价值。方法随机选取2015年10月~2016年10月在合肥市第二人民医院心血管内科住院行冠状动脉造影检查的患者,经过造影证实非冠心病患者115例,冠心病患者161例。通过队列研究及Logistic回归分析评估生化指标HCY、GGT和冠心病的相关性。结果两组在年龄、高血压病史、三酰甘油、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、载脂蛋白A、载脂蛋白B、尿酸、总胆红素、间接胆红素、HCY、GGT水平上差异有统计学意义(P<0.05)。HCY、GGT和冠脉狭窄程度(Gensini)评分均呈正相关(r=2.18、2.42,P<0.05)。多因素Logistic回归分析结果示,HCY、GGT是冠心病的独立危险因素(P<0.01,95%CI:1.035~1.167;P<0.01,95%CI:1.083~1.175)。受试者工作曲线提示当HCY=11.80 mmol/L时为预测冠心病最佳割点。曲线下面积0.686。结论血清生化指标HCY、GGT是冠心病的独立危险因素,且与冠脉的狭窄程度存在相关性。HCY对于临床诊断冠心病具有一定价值。Objective To explore the correlation between homoeysteinemia （HCY）, glutamyhransferase （GGT） and coronary heart disease and the degree of coronary artery stenosis. Methods Patients who underwent coronary angiography in the Second People＇s Hospital of Hefei fi＇om October 2015 to October 2016 were selected randomly as the research subjects. They were divided into normal group （115 cases） and coronary heart disease group （161 cases） based on the results of diagnostic coronary angiography. Results The two groups had significant differences in age, hypertension history, triaeylglyeerol, total cholesterol, high-density lipoprotein ehdesterol, low density lipoprotein, apolipoprotein A, apolipoprotein B, uric acid, total bilirubin, indirect bilirubin, HCY and GGT （P 〈 0.05）. According to linear correlation analysis, the levels of HCY and GGT were positively correlated with coronary Gensini scores （r = 2.18, 2.42, P 〈 0.05）. Multivariate Logistic＂ regression analysis showed that HCY and GGT were independent risk factors of coronary heart dis ease （P 〈 0.0l, 95%CI： 1.035-1.167; P 〈 0.01, 95%CI： 1.083-1.175）. In a receiver operating characteristic （ROC） curve, the HCY value of 11.80 retool/1 was identified as an effective cut-point in the coronary heart disease and the area under curve was 0.686. Conclusion HCY and GGT are independent risk factors of coronary heart disease and they are positively correlated with the degree of coronary artery stenosis. HCY is an indicator of diagnosis of coronary heart disease.

关 键 词：血清生化指标 同型半胱氨酸 谷氨酰转移酶 冠心病 GENSINI评分 

分 类 号：R541[医药卫生—心血管疾病]