抗雄激素治疗后多囊卵巢综合征患者的产科结局  

Obstetric Outcome In Patients With Polycystic Ovary Syndrome After Antiandrogen Therapy

作　　者：高蓓 王志新[1] Gao Bei;Wang Zhixin(Department of Gynecology,The First Affiliated Hospital of Jinan University,Guangzhou,Guangdong,510000,China)

机构地区：[1]暨南大学附属第一医院妇科,广东广州510000

出　　处：《当代医学》2018年第26期115-117,共3页Contemporary Medicine

摘　　要：目的探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者经抗雄激素治疗(炔雌醇环丙孕酮片)后的是否降低不良妊娠结局(自然流产、妊娠期糖尿病、妊娠期高血压疾病、早产)及新生儿不良结局(低出生体质量儿、巨大儿及新生儿重症监护室)的发生率。方法回顾性分析2011年1月~2016年12月于暨南大学附属第一医院妇产科就诊的PC0S单胎妊娠患者120例,63例抗雄激素治疗患者为研究组,57例未治疗患者为对照组。对比两组患者的一般情况;比较两组治疗前后血清性激素指标(E2、FSH、LH、PRL、T、LH/FSH);对比两组患者孕期并发症(自然流产、妊娠期糖尿病、妊娠期高血压疾病)及新生儿情况(低出生体重儿、巨大儿、早产及新生儿重症监护室)等的发生率。结果研究组患者治疗后的血清T(P=0.000)、LH/FSH(P=0.030)低于对照组,差异有统计学意义(P<0.05);两组患者的血清E2、FSH、LH、PRL相比差异无统计学意义。研究组患者孕期并发症自然流产(P=0.010)、妊娠期糖尿病(P=0.007)、妊娠期高血压疾病(P=0.001)、早产(P=0.003)的发生率均低于对照组。研究组新生儿入住新生儿重症监护室(P=0.000)的发生率低于对照组;两组低出生体质量儿、巨大儿的发生率对比差异无统计学意义。结论采用抗雄激素治疗多囊卵巢综合征的临床疗效明显,多囊卵巢综合征的妊娠期并发症和新生儿不良情况发生率均显著降低。Objective To investigate whether the treatment of patients with polycystic ovary syndrome （PCOS） after anti-androgen treatment （ethinylestradiol and cyproterone acetate tablet） reduces adverse pregnancy outcomes （natural abortion, gestational diabetes, gestational hypertension,preterm delivery and The incidence of neonatal adverse outcomes （low birth weight infants, macrosomia, and neonatal intensive care unit）.Methods We retrospectively analyzed 120 patients with PC0S singleton pregnancies who were attending the Department of Obstetrics and Gynecology at the First Affiliated Hospital of Jinan University from January 2011 to December 2016. Sixty-three patients treated with anti-androgen were studied, and 57 patients were untreated Control group. The general conditions of the two groups of patients were compared; serum sex hormones （E2,FSH, LH, PRL, T, and LH/FSH） were compared before and after treatment in the control and study groups; pregnancy complications （spontaneous abortion, gestational diabetes, Pregnancy hypertensive disease） and neonatal conditions （low birth weight infants, macrosomia, preterm labor, and neonatal intensive care unit）. Results The serum T （P=0.000） and LH/FSH （P=0.030） were lower in the study group than those of the control group.There was no statistical difference between the serum E2, FSH, LH, and PRL in the two groups. Learn differences. The incidence of complications such as spontaneous abortion （P=0.010）, gestational diabetes （P=0.007）, hypertensive disorder during pregnancy （P=0.001） and premature delivery （P=0.003） was lower in the study group than during the control group. The incidence of neonatal intensive care unit （P=0.000） was lower in the study group than in the control group; there was no significant difference in the incidence of low birth weight and macrosomia between the two groups.Conclusion The clinical efficacy of anti-androgens in the treatment of polycystic ovary syndrome is significant, and the incidence of c

关 键 词：多囊卵巢综合征 妊娠期糖尿病 妊娠期高血压疾病 低出生体质量儿 巨大儿 早产 新生儿重症监护室 

分 类 号：R711.75[医药卫生—妇产科学]