类风湿关节炎合并肺间质病变患者血清肿瘤标志物的变化及临床意义  

Changes and clinical significance of serum tumor markers in patients with rheumatoid arthritis combined with interstitial lung disease

作　　者：张剑[1] 李杰[2] 于欣 解洁[4] ZHANG Jian;LI Jie;YU Xin;XIE Jie(Department of Rheumatology and Immunology,Weihai Municipal Hospital in Shandong Province,Weiha 264200,China;Department of Science and Education,Weihai Municipal Hospital in Shandong Province,Weihai 264200,China;Department of TCM Nephrology,Weihai Hospital of Traditional Chinese Medicine in Shandong Province,Weihai 264200,China;Quality Management Office,Weihai Municipal Hospital in Shandong Province,Weihai 264200,China)

机构地区：[1]山东省威海市立医院风湿免疫科 [2]山东省威海市立医院科教科 [3]山东省威海市中医院中医肾病内科 [4]山东省威海市立医院质管办,山东威海264200

出　　处：《海南医学院学报》2018年第18期1666-1668,1673,共4页Journal of Hainan Medical University

基　　金：卫生科技发展计划项目(2016WS0638)~~

摘　　要：目的:探讨类风湿关节炎(RA)合并肺间质病变患者血清肿瘤标志物的变化及临床意义。方法:健康志愿者50例作为正常对照组、单纯类风湿性关节炎患者47例作为RA组、类风湿关节炎合并肺间质病变患者28例作为合并病变组。对比3组研究对象血清中肿瘤标志物、RA标记物、炎症介质含量的差异,采用Pearson检验评估RA合并肺间质病变患者血清肿瘤标志物含量与RA标记物、炎症介质的相关关系。结果:合并病变组血清中肿瘤标志物CA199、CA153、CEA的含量高于RA组;RA标记物RF、GPI的含量高于RA组,CCP、AKA的含量与RA组比较无显著性差异;炎症介质HMGB1、GMCSF、IL-6、IL-17、IL-27的含量高于RA组。相关性分析发现,RA合并肺间质病变患者血清中肿瘤标志物CA199、CA153、CEA的含量与RF、GPI、HMGB1、GM-CSF、IL-6、IL-17、IL-27的含量呈正相关。结论:RA合并肺间质病变患者血清中肿瘤标志物CA199、CA153、CEA的含量异常增高,且具体含量与患者病情严重程度直接相关。Objective： To investigate the changes and clinical significance of serum tumor markers in patients with rheumatoid arthritis （RA） combined with interstitial lung disease. Methods： 50 healthy volunteers were chosen as the normal control group, 47 patients with rheumatoid arthritis alone were chosen as the RA group, and 28 patients with rheumatoid arthritis combined with interstitial lung disease were chosen as combined disease group. The differences in the levels of serum tumor markers, RA markers and inflammatory mediators were compared among the three groups, and Pearson test was used to evaluate the correlation of serum tumor marker levels with RA markers and inflammatory mediators in patients with RA combined with interstitial lung disease. Results： Serum tumor markers CA199, CA153 and CEA levels of combined disease group were higher than those of RA group（ P 〈0.05）; RA markers RF and GPI levels were higher than those of RA group whereas CCP and AKA levels were not significantly different from those of RA group; inflammatory mediators HMGB1, GM-CSF, IL-6, IL-17 and IL-27 levels were higher than those of RA group. Correlation analysis showed that serum tumor markers CA199, CA153 and CEA levels in patients with RA combined with interstitial lung disease were positively correlated with RF, GPI, HMGB1, GM-CSF, IL-6, IL-17 and IL-27 levels. Conclusion： Serum tumor markers CA199, CA153 and CEA levels abnormally increase in patients with RA combined with interstitial lung disease, and the specific levels are directly correlated with the disease severity.

关 键 词：类风湿关节炎 肺间质病变 肿瘤标志物 

分 类 号：R593.22[医药卫生—内科学] R563[医药卫生—临床医学]