生物力药理学研究进展  

Development of Biomechanopharmacology

作　　者：张倩[1] 刘蕾 游云[1] 廖福龙[1] ZHANG Qian;LIU Lei;YOU Yun;LIAO Fulong(Chinese Materia Medica,China Academy of ChineseMedical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700

出　　处：《中国药物警戒》2018年第8期467-469,共3页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金(81274006):基于生物力药理学的丹参药效机理研究;中国中医科学院基本科研业务费自主选题项目(ZZ11-044):基于Piezo1离子通道研究三七抗血小板聚集的生物力药理学机制

摘　　要：本文从血流剪应力具有多靶点生物学效应阐释了生物力药理学的提出背景,并对近年来基于生物力药理学所开展的活血化瘀中药研究和抗血小板聚集药物研究的进展进行了总结分析。提出通过建立生物力药理学药物筛选模型,从机械力离子通道的角度发现抗血小板聚集的中药及化合物。This paper reveals formation of the borderline discipline of biomechanopharmacology from the multi-targeted biological effects of shear stress. It reviews the recent biomechanopharmacological studies of herbs with activating blood circulation and removing thrombosis effects, together with such studies of compounds with anti-platelets aggregation effects. We are looking forward to screening Chinese herbs through mechanical ion channel activator or inhibitor by means of biomechanopharmacology.

关 键 词：生物力药理学 血流剪应力 抗血小板聚集 

分 类 号：R965[医药卫生—药理学]