薯蓣皂苷药理作用、潜在肝毒性及药代动力学研究进展  

Progress of Pharmacology, Potential Hepatotoxicity and Pharmacokinetics of Dioscin

作　　者：罗攀 吕春明 周文斌 寇芳 魏海 LUO Pan;LV Chunming;ZHOU Wenbin;KOU Fang;WEI Hai(Institute of Interdisciplinary ComplexResearch,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Zhulian IntelligentTechnology Co.,Ltd.,Shanghai 201323,China)

机构地区：[1]上海中医药大学交叉科学研究院,上海201203 [2]上海铸连智能科技有限公司,上海201323

出　　处：《中国药物警戒》2018年第8期493-498,共6页Chinese Journal of Pharmacovigilance

摘　　要：薯蓣皂苷属于甾体皂苷中的异螺旋甾烷醇型衍生物,是多种植物药、中成药和中药复方的药效物质基础及质控成分。文章综述了近年来薯蓣皂苷的药理学作用、潜在肝毒性及药代动力学研究成果。薯蓣皂苷药理作用广泛,尤其在心血管药理方面,临床应用潜力巨大,但其潜在的肝毒性需要被关注,同时药代动力学方面其胃肠道吸收差、代谢缓慢并且生物利用度极低,亦需被关注。薯蓣皂苷的肝毒性与剂量相关,由于薯蓣皂苷存在潜在的肝毒性,临床应用相关药物时应加以防范。Dioscin is an iso-spirostanol derivative. It is the major effective component for the quality control of many herbal medicines, Chinese patent medicines and herbal medicine prescriptions. This paper reviewed the researches on the pharmacology, hepatotoxicity and pharmacokinetics of dioscin in recent years. Dioscin has many pharmacological effects, especially in the cardiovascular regulation. However, the potential hepatotoxicity of dioscin should be paid more attention. Its poor absorption, slow metabolism and low bioavailability should also be noticed. The dose-dependent hepatotoxicity of dioscin should be taken into account for the safety of the prescriptions containing dioscin in clinic.

关 键 词：薯蓣皂苷 药理作用 肝毒性反应 药代动力学 

分 类 号：R965[医药卫生—药理学]