GC法测定阿托伐他汀钙关键中间体ATS-9  

Determination of the Key Intermediate( ATS-9)of Atorvastatin Calcium by GC

作　　者：吕一甫 徐桂清[2] 郝乐辰 曾淑芸 李杰 贾淑红[2] 姜玉钦 李伟[2] L Yi-fu;XU Gui-qing;HAO Yue-chen;ZENG Shu-yun;LI Jie;JIA Shu-hong;JIANG Yu-qin;LI Wei(Topfond Pharmaceutical Co,Ltd.,Zhumadian 463000,China;,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007)

机构地区：[1]天方药业有限公司,河南驻马店463000 [2]河南师范大学化学化工学院,河南新乡453007

出　　处：《合成化学》2018年第9期695-698,共4页Chinese Journal of Synthetic Chemistry

基　　金：河南省科技创新人才项目(164100510015);国家级大学生创新训练计划项目(201610476087)

摘　　要：建立了一种检测阿托伐他汀钙关键中间体(ATS-9)含量的气相色谱法。采用Agilent DB-624(30 m×0. 32mm,1. 8μm)毛细管气相色谱柱,高纯氮为载气,氢火焰离子化检测器检测,程序升温,1,2-二氯乙烷为稀释溶剂,正十六烷为内标物。ATS-9在0. 812 8~4. 063 8 mg·mL^(-1)(r=0. 999 5)范围内,线性关系良好,平均回收率为99. 68%,RSD为1. 26%。A GC method was established for the determination of ATS-9, the key intermediate of atorvastatin calcium. An Agilent DB-624（30 m×0.32 mm, 1.8 μm） capillary column was used with nitrogen as the carrier gas and FID as the detector in temperature program mode. 1,2-Dichloroethane was dilution solvent, and n -hexadecane was internal standard. The calibration curves for ATS-9 was linear in the concentration range of 0.812 8~4.063 8 mg·mL -1 （ r =0.999 5）. The average recovery was 99.68% with RSD of 1.26%.

关 键 词：阿托伐他汀钙中间体 ATS-9 气相色谱 含量测定 

分 类 号：O657.71[理学—分析化学]