阻塞性睡眠呼吸暂停低通气综合征与焦虑抑郁及认知功能障碍相关研究  

Correlation between anxiety,depression and cognition impairment in patients with obstructive sleep apnea-hypopnea syndrome

作　　者：翟曜耀 刘晓霞[2] 吴大海[1] 李树华[1] ZHAI Yao-yao,LIU Xiao-xia,WU Da-hai,LI Shu-hua(Department of Otolaryngology,The General Hospital of Shenyang Military Command,Shenyang 110016,Chin)

机构地区：[1]沈阳军区总医院耳鼻喉科,辽宁沈阳110016 [2]中国医科大学附属盛京医院放射科,辽宁沈阳110004

出　　处：《临床军医杂志》2018年第9期1008-1010,共3页Clinical Journal of Medical Officers

基　　金：辽宁省自然科学基金(201602795)

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与焦虑、抑郁等不良精神心理情绪以及认知功能下降的相关性。方法收集自2016年6月至2017年3月就诊于沈阳军区总医院耳鼻咽喉科行多导睡眠呼吸监测检查并能够配合完成认知功能及抑郁、焦虑相关精神心理量表评估的106例患者为研究对象,其中,72例符合OSAHS诊断为OSAHS组,34例不符合OSAHS诊断为非OSAHS组。分别记录患者呼吸暂停低通气指数(AHI)、最低血氧饱和度(LSO2)及贝克焦虑量表(BAI)、贝克抑郁量表第二版(BDI-Ⅱ)、蒙特利尔认知评估量表(MoCA)的评分值,并分析其相关性。结果 OSAHS组患者AHI、BAI评分及BDI-Ⅱ评分明显高于非OSAHS组,LSO2、MoCA评分明显低于非OSAHS组,组间比较,差异有统计学意义(P <0. 05)。AHI与BAI评分、BDI-Ⅱ评分呈正相关(r=0. 488、0. 452,P <0. 05),与MoCA评分呈负相关(r=-0. 712,P <0. 05);LSO2与BAI评分、BDI-Ⅱ评分呈负相关(r=-0. 426、-0. 375,P <0. 05),与MoCA评分呈正相关(r=0. 572,P <0. 05)。MoCA评分与BAI评分及BDI-Ⅱ评分无相关性(P> 0. 05)。结论 OSAHS可以诱发患者产生负面的精神心理情绪以及认知功能下降,且与AHI、LSO2指标密切相关。Objective To investigate the relationship between cognition impairment,anxiety and depression in patients with obstructive sleep apnea-hypopnea syndrome（OSAHS）.Methods A retrospective study was performed on 106 cases of patients who performed sleep apnea monitoring inspection and able to cooperate to complete the cognitive function and related mental depression and anxiety from June 2016 to March 2017.There were 72 cases of OSAHS were diagnosed as OSAHS group,and 34 cases of OSAHS were diagnosed as non-OSAHS group.Patients with apnea hypoventilation index（AHI）,lowest blood oxygen saturation（LSO 2） and beck anxiety inventory（BAI）,the second version of the beck depression inventory（BDI-Ⅱ）,Montreal cognitive assessment scale（MoCA） score values were recorded and their relevance was analyzed.Results AHI,scores of BAI and BDI-Ⅱ of OSAHS group were significantly higher than those of the non-OSAHS group,the scores of LSO 2 and MoCA of OSAHS group were significantly lower than those of the non-OSAHS group（ P 〈0.01）.The correlation between AHI and the scores of BAI and BDI-Ⅱ were positive（ r =0.488,0.452, P 〈 0.05）,and the correlation between AHI and the score of MoCA was negative（ r =-0.712, P 〈0.05）.The correlation between LSO 2 and the score of BAI and BDI-Ⅱ were negative（ r =-0.426,-0.375, P 〈0.05）,and the correlation between LSO 2 and score of MoCA was positive（ r =0.572, P 〈0.05）.There was no relationship between the scores of MoCA,BAI and BDI-Ⅱ（ P 〉0.05）.Conclusion OSAHS can induce negative psychological mood and cognition impairment in the patients,these changes of brain function have close relationship with AHI and LSO 2.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 焦虑 抑郁 认知功能障碍 

分 类 号：R766[医药卫生—耳鼻咽喉科]