大鼠原位单向肠灌流模型研究两种多糖类药物肠道降解动力学  

Study on Intestinal Degradation Kinetics of Two Kinds of Polysaccharides Using In Situ Single Plass Perfusion Model in Rats

作　　者：邵华荣 房绍英 吴季栩 刘飞 马河 凌沛学 程艳玲 SHAO Hua-rong;FANG Shao-ying;WU Ji-xu;LIU Fei;MA He;LING Pei-xue;CHENG Yan-ling(Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China)

机构地区：[1]山东省药学科学院,山东济南250101

出　　处：《食品与药品》2018年第5期333-335,共3页Food and Drug

基　　金：山东省自然科学基金博士基金(ZR201702210154);山东省糖产业科学技术重点实验室联盟(SWZX 2016002)

摘　　要：目的研究贻贝多糖和人参多糖在大鼠肠道内的降解特性。方法采用大鼠原位单向肠灌流模型,采用高效液相色谱法(HPLC)测定两种多糖在肠灌流液中的含量。结果贻贝多糖在十二指肠段全部降解,在空肠段的降解百分率为40.33%±15.65%,在回肠和结肠部位,贻贝多糖降解百分率较低,分别为0.70%±0.49%和0.30%±0.14%。人参多糖在各肠段均有不同程度降解,其中,回肠部位的降解百分率较大,为52.41%±13.14%,结肠部位降解较少,仅为0.68%±0.54%。十二指肠和空肠部位的降解百分率分别为25.19%±17.02%和33.04±15.26%。结论贻贝多糖及人参多糖均可在肠道发生降解。Objective To study the degradation kinetics of ginseng polysaccharide （GP） and mussel polysaccharide （MP） in the intestinal tracts of rats. Methods The in situ single plass perfusion model in rats was used, and the contents of the polysaccharides in the intestinal perfusion fluid were determined by HPLC. Results The MP could be degraded completely in duodenum. The degradation percent of MP was 40.33 %±15.65 %, 0.70 %±0.49 % and 0.30 %±0.14 % in jejunum, ileum and colon, respectively. The GP had different degradation degrees in each bowel segment. The degradation percent of GP was 25.19 %±17.02 %, 33.04 %±15.26 %, 52.41 %±13.14 % and 0.68 %±0.54 % in duodenum, jejunum, ileum and colon, respectively. Conclusions After oral administration, GP and MP could be both degraded in the intestinal tracts.

关 键 词：贻贝多糖 人参多糖 肠道降解 原位单向肠灌流 

分 类 号：R969.1[医药卫生—药理学]