男性HIV感染患者性激素代谢、T淋巴细胞亚群的变化及性功能障碍发生情况分析  

Changes of sex hormones metabolism and T lymphocyte subsets and the incidence of sexual dysfunction in male patients with HIV infection

作　　者：周兴雯 徐蕾[2] 赵皓森 周文瑞[1] 彭红霞[1] ZHOU Xingwen;XU Lei;ZHAO Haosen;ZHOU Wenrui;PENG Hongxia(Department of Dermatology,Liangshan Second People＇s Hospital,Xichang 615000,Sichuan,China;Department of Traditional Chinese Medicine Surgery,Liangshan Second People＇s Hospital,Xichang 615000,Sichuan,China)

机构地区：[1]凉山州第二人民医院皮肤科,四川西昌615000 [2]凉山州第二人民医院中医外科,四川西昌615000

出　　处：《中国性科学》2018年第7期24-26,共3页Chinese Journal of Human Sexuality

摘　　要：目的:分析探讨男性患者感染HIV对其性激素代谢、T淋巴细胞亚群的影响以及性功能障碍的发生情况。方法:选取2014年5月至2016年1月凉山州第二人民医院收治的HIV感染男性患者79例作为感染组,选取同期来医院健康体检的男性45例作为正常对照组。检测和比较两组成员性激素水平、T淋巴细胞亚群数量和百分比,以及通过国际勃起功能指数-5量表(International Index of Erectile Function,IIEF-5)判定两组成员性功能障碍发生情况。结果:(1)6项性激素水平测定中,HIV感染组患者睾酮(T)、孕酮(P)和泌乳素(PRL)浓度明显低于正常对照组患者,而人促黄体生成激素(LH)、雌激素(E_2)和人血清促卵泡生成激素(FSH)则显著高于正常对照组患者;(2)T淋巴细胞亚群测定结果比较,HIV感染组患者CD3+和CD4+T细胞数量和百分比较正常对照组患者皆明显下降,CD8+T细胞数量和百分比测定结果高于正常对照组患者;(3)男性HIV感染组患者出现性功能障碍比率明显高于正常对照组患者,其中以轻度勃起功能障碍(erectile dysfunction,ED)为主,共出现50例,占比63.29%。结论:男性感染HIV容易造成机体性腺功能减退,性激素代谢水平下降,T淋巴细胞亚群数量与比例失衡,同时也会造成性功能障碍。Objective： To investigate the effect of HIV infection on sex hormone metabolism and T lymphocyte subsets and the incidence of sexual dysfunction in male patients. Methods： 79 cases of male patients with HIV infection treated in Liangshan Second People＇s Hospital from May 2014 to January 2016 were selected,and another 45 cases of normal men were selected as the normal control group at the same time. Levels of sex hormones,amount and percentage of T lymphocyte subsets were compared between the two groups,and the incidence of sexual dysfunction in the two groups was evaluated with the International Erectile Function Index-5 （IIEF-5）. Results： Among six sex hormones,levels of testosterone （T）,progesterone （P） and prolactin （PRL） in HIV infection group were significantly lower than those in the normal control group,while levels of human luteinizing hormone （LH）,estrogen （E_2）and human serum follicle stimulating hormone （FSH） were significantly higher than those in the normal control group.The amount and percentage of CD3 ＋ and CD4 ＋ T cells in HIV infection group were significantly lower than those in the normal control group,while the number and percentage of CD8 ＋ T cells were significantly higher than those in the normal control group. The incidence of sexual dysfunction in HIV infection group was significantly higher than that in the normal control group,and the main sexual dysfunction was erectile dysfunction （ED） in 50 cases （63. 29%）.Conclusions： HIV infection in men is likely to cause the decrease of gonadal function and the level of sex hormone metabolism,and result in the imbalance of the amount and percentage of T lymphocyte subsets and sexual dysfunction.

关 键 词：人类免疫缺陷病毒 性激素 T淋巴细胞亚群 性功能障碍 

分 类 号：R512.91[医药卫生—内科学]