白细胞介素-6在青光眼发病过程中的作用  

Role of interleukin-6 in the pathogenesis of glaucoma

作　　者：刘攀 孟杰[1] 刘星 王强[1] Pan Liu, Jie Meng, Xing Liu, Qiang Wang(Department of Ophthalmology, Binzhou Medical University Hospital,Binzhou 256603, Shandong Province, Chin)

机构地区：[1]滨州医学院附属医院眼科,中国山东省滨州市256603

出　　处：《国际眼科杂志》2018年第10期1803-1805,共3页International Eye Science

基　　金：山东省科学技术发展计划项目(No.2012YD18117)~~

摘　　要：青光眼是全球范围内第二位致盲性眼病,其发病原理目前尚不十分明确,治疗方面多从对症治疗、降低眼压方面进行,以降低青光眼对视神经的不可逆损伤。房水中含有大量的细胞因子,包括促炎性因子、氧化应激因子、生长因子等,这些细胞因子在青光眼发病及预后过程中均起到至关重要的作用。白细胞介素-6(interleukin-6, IL-6)作为最常见的促炎性因子之一,近年来成为众多国内外临床试验监测的对象。本文旨在综述IL-6在青光眼发病过程中的作用。Glaucoma is the second cause of the blindness in the world,and there is no clear pathogenesis about it. What we can do nowadays is only studying symptomatic treatment including the reduction of the intraocular pressure and so on. Only by this can we reduce the irreversible damage of the optic nerve caused by glaucoma. Aqueous humor contains a large number of cytokines,including pro-inflammatory factors,oxidative stress factors,growth factors,etc. These cytokines play a vital role in the pathogenesis and prognosis of the glaucoma. As one of the most common pro-inflammatory factors,interleukin-6（ IL-6） becoming the object of many clinical trials both here and abroad in recent years. This paper summarizes both the mechanism of glaucoma injury and the role of IL-6 in it. And from this article we can analyze the relationship between interleukin-6 and glaucoma for developing new ideas about treatments of glaucoma in the future.

关 键 词：青光眼 小梁网 房水 白细胞介素-6 眼压 

分 类 号：R541.4[医药卫生—心血管疾病]