艾滋病血清白蛋白、β2微球蛋白和白介素-8水平与肾功能的关系  

Correlation between the serum levels of albumin,β2-microglobulin,interleukin 8 and renal function of patients with AIDS

作　　者：蒋奕[1] 胡腾 江成巧 JIANG Yi;HU Teng;JIANG Chengqiao(Department of Infectious Diseases,No.404 Hospital of Mianyang City,Sichuan,Mianyang 621000,China)

机构地区：[1]四川绵阳四0四医院传染科,621000

出　　处：《河北医药》2018年第20期3068-3072,共5页Hebei Medical Journal

基　　金：四川省医学会科研课题计划(编号:S16060)

摘　　要：目的探讨艾滋病血清白蛋白(ALB)、β2微球蛋白(β2-MG)和白介素-8(IL-8)水平与其肾功能的关系。方法选取初治艾滋病患者128例为研究的对象,患者均接受相应治疗且每个月对其血清ALB、β2-MG、IL-8水平、24 h尿蛋白以及肾小球滤过率(GFR),连续检测1年。采用Pearson线性相关分析法分析其血清ALB、β2-MG、IL-8水平与24 h尿蛋白和GFR的关系。结果与治疗前比较,患者治疗3个月、6个月以及治疗1年的血清ALB水平和GFR均降低,同期血清β2-MG、IL-8水平和24 h尿蛋白则均升高(P <0. 05)。与GFR≥60 ml/min患者比较,治疗前、治疗3个月、6个月以及治疗1年GFR <60 ml/min患者的血清ALB水平降低而血清β2-MG、IL-8水平和24 h尿蛋白升高(P <0. 05)。与24 h尿蛋白<1 000 mg患者比较,治疗前、治疗3个月、6个月以及治疗1年24 h尿蛋白≥1 000 mg患者的血清ALB水平降低而血清β2-MG、IL-8水平升高(P <0. 05)。Pearson线性相关分析结果显示,患者血清ALB水平与其24 h尿蛋白呈现负相关(r=-0. 768,P <0. 05),与其GFR则呈正相关(r=0. 844,P <0. 05);患者血清β2-MG、IL-8水平与其24 h尿蛋白呈现正相关(r=0. 856,0. 878,P <0. 05),与其GFR则呈负相关(r=-0. 875,-0. 892,P <0. 05)。结论艾滋病血清ALB、β2-MG和IL-8水平与其肾功能密切相关,通过补充营养提高ALB水平和采取措施降低β2-MG和IL-8水平可能有助于艾滋病肾功能损伤的控制。Objective To investigate the relationship between the serum levels of albumin （ALB）,β2-microglobulin （β2-MG）,interleukin 8 （IL-8） and renal function of patients with AIDS. Methods A total of 128 patientssss with AIDS who received corresponding treatment in our hospital were enrolled in the study. The serum levels of ALB,β2-MG and IL-8,24 hours urine protein and glomerular filtration rate （GFR） were detected every month for one year.Pearson linear correlation analysis method was used to analyze the relationship between the serum levels of ALB,β2-MG, IL-8 and 24-hour urine protein as well as GFR. Results As compared with those before treatment,the serum levels of ALB and GFR at 3m,6m,1y after treatment in patients with AIDS were significantly decreased,however,the serum levels of β2-MG,IL-8 and 24-hour urine protein were significantly increased （ P 〈0.05）.As compared with those of patients with GFR≥60ml/min,the serum levels of ALB before treatment and at 3m,6m,1y after treatment were significantly decreased,however,the serum levels of β2-MG,IL-8 and 24-hour urine protein were significantly increased （ P 〈0.05）. As compared with those of patients with 24-hour urine protein〈1000mg,the serum levels of ALB before treatment and at 3m,6m,1y after treatment were significantly decreased,however,the serum levels of β2-MG and IL-8 were significantly increased （ P 〈0.05）.Pearson linear correlation analysis showed that the levels of ALB of patients were negatively correlated with those of 24-hour urinary protein （ r =-0.768, P 〈 0.05 ）,however,which were positively correlated with those of GFR （ r =0.844, P 〈0.05）,moreover,the levels β2-MG and IL-8 of patients were positively correlated with those of 24-hour urine protein （ r =0.856,0.878,respectively, P 〈0.05）,however,which were negatively correlated with those of GFR （ r =-0.875,-0.892,respectively, P 〈0.05）. Conclusion The serum levels of ALB,β2-MG and IL-8 in patients with AIDS are closely correlate

关 键 词：艾滋病 白蛋白 Β2微球蛋白 白介素8 肾功能 关系 

分 类 号：R512.91[医药卫生—内科学]