生长抑素联合埃索美拉唑对消化道出血患者的血流动力学影响及安全性分析  

The effects of somatostatin combined with esomeprazole on hemodynamics in patients with gastrointestinal hemorrhage and its safety analysis

作　　者：乔京贵[1] 赵聪亚 QIAO Jinggui;ZHAO Congya(Department of Digestive Diseases,Gaoxin Hospital of Xi＇an City,Shaanxi,Xi＇an 710075,China)

机构地区：[1]西安高新医院消化科,西安市710075

出　　处：《河北医药》2018年第20期3081-3084,共4页Hebei Medical Journal

摘　　要：目的探讨生长抑素联合埃索美拉唑对消化道出血患者血流动力学的影响及其安全性。方法选取2014年1月至2017年1月消化道出血患者114例,采用随机数字表法将患者分为联合治疗组与常规治疗组,每组57例,常规治疗组采用埃索美拉唑治疗,联合治疗组采用生长抑素联合埃索美拉唑治疗,采用彩色多普勒超声诊断仪测定血流动力学参数(脾静脉、门静脉内径与血流量),比较2组临床疗效、血流动力学参数与不良反应率的差异。结果联合治疗组治疗总有效率明显高于常规治疗组,平均止血时间与平均住院时间均明显短于常规治疗组,2组比较差异有统计学意义(P <0. 05)。治疗前,2组脾静脉内径、门静脉内径、脾静脉血流量与门静脉血流量比较差异无统计学意义(P> 0. 05),治疗后,全部患者上述指标明显低于治疗前,联合治疗组上述指标明显低于常规治疗组,比较差异有统计学意义(P <0. 05)。联合治疗组再出血率与不良反应率明显低于常规治疗组,2比较差异有统计学意义(P <0. 05)。结论生长抑素联合埃索美拉唑对消化道出血患者的临床疗效满意,可明显缩短止血时间,改善血流动力学参数,且药物安全性较高,值得临床推广应用。Objective To investigate the effects of somatostatin combined with esomeprazole on hemodynamics in patients with gastrointestinal hemorrhage （GIH） and its safety. Methods A total of 114 patients with GIH who were treated in our hospital from January 2014 to January 2017 were enrolled in the study. The patients were divided into combination treatment group （ n =57） and conventional treatment group （ n =57） according to random number table. The patients in conventional treatment group were treated with esomeprazole, while those in combination treatment group were treated with somatostatin combined with esomeprazole. The hemodynamic parameters including diameter and blood flow volume of splenic vein as well as portal vein were measured by color Doppler ultrasound. The changes of clinical efficacy, hemodynamic parameters and adverse reactions were observed and compared between the two groups. Results The total effective rate in combination treatment group was significantly higher than that in conventional treatment group. The mean duration of hemostasis and hospitalization was significantly shorter than that in conventional treatment group, and there were significant differences between two grousp （ P 〈0.05）. Before treatment, there were no significant differences in the diameter and blood flow volume of splenic vein and portal vein between the two groups （ P 〉0.05）. Nonetheless, after treatment, the indexes mentioned above in all the patients were significantly lower than those before treatment, moreover,which in combination treatment group were significantly lower than those in conventional treatment group （ P 〈0.05）. The rebleeding rate and incidence rate of adverse reaction in combination treatment group were significantly lower than those in conventional treatment group （ P 〈0.05）. Conclusion For patients with GIH, somatostatin combined with esomeprazole can obtain satisfactory clinical efficacy, which can significantly shorten the duration of hemostasis and improve hemody

关 键 词：生长抑素 埃索美拉唑 消化道出血 血流动力学参数 安全性 

分 类 号：R57[医药卫生—消化系统]