钙离子拮抗剂类降压药的临床应用与不良反应分析  

Clinical Application and Adverse Reaction Analysis of Calcium Antagonist Antihypertensive Drugs

作　　者：袁敏[1] 周袁成 YUAN Min;ZHOU Yuan-cheng(Department of Pharmacy,Shanggao County People＇s HospitaI,Shanggao 336400,Jiangxi,China;the First Clinical Medical College,Nanchang University,Nanchang 330031,Jiangxi,China)

机构地区：[1]江西省上高县人民医院药剂科,江西上高336400 [2]南昌大学第一临床医学院,江西南昌330031

出　　处：《医学信息》2018年第17期125-127,共3页Journal of Medical Information

摘　　要：目的对钙离子拮抗剂类降压药的临床应用与不良反应进行研究。方法选取我院2015年1月~2017年12月收治的52例使用钙离子拮抗剂类降压药治疗发生心脏不良反应患者,对其临床资料及临床治疗、不良反应等情况进行统计分析。结果患者不良反应发生与性别无明显关系,与年龄存在较大关系,P<0.05;且以二氢吡啶类钙离子拮抗剂导致的不良反应患者数量最高,约为94.23%,临床中以心悸、心律失常、心动过速、房室传导阻滞以及心脏骤停等反应为主,其中出现心悸的患者数量最多,约为76.92%。结论钙离子拮抗剂类降压药物应用于高血压患者的临床治疗,应做好心脏不良反应监测,分析患者服药治疗期间心脏不良反应,以促进临床合理用药治疗。Objective To study the clinical application and adverse reactions of calcium antagonist antihypertensive drugs.Methods A total of 52 patients with cardiac allergic reactions were treated with calcium antagonists and antihypertensive drugs from January 2015 to December 2017.The clinical data,clinical treatment and adverse reactions were statistically analyzed.Results There was no significant relationship between adverse reactions and gender,and there was a significant relationship with age,P〈0.05.The number of patients with adverse reactions caused by dihydropyridine calcium antagonists was the highest,about 94.23%.Clinically,palpitations,arrhythmia,tachycardia,atrioventricular block,and cardiac arrest were the main reactions.Among them,the number of patients with palpitations was the highest,about 76.92%.Conclusion Calcium antagonist antihypertensive drugs are used in the clinical treatment of patients with hypertension.Cardiac adverse reactions should be monitored and the adverse reactions of the patients during drug treatment should be analyzed to promote clinical rational drug treatment.

关 键 词：钙离子拮抗剂 不良反应 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]