宫颈病变患者TWIST与E-Cadherin表达水平的相关性分析  

Correlation analysis of TWIST and E-Cadherin expression levels in patients with cervical lesions

作　　者：黄武 邓晓杨[2] 樊元春[3] 景诗学 HUANG Wu;DENG Xiaoyang;FAN Yuanchun;JIN Shixue(Department of Obstetrics and Gynecology,People s Hospital of Pidu District,Chengdu 611730,Sichuan,Chengdu)

机构地区：[1]成都市郫都区人民医院妇产科,四川成都611730 [2]成都医学院第一附属医院妇产科 [3]成都医学院第一附属医院病理科 [4]成都市郫都区人民医院病理科

出　　处：《中南医学科学杂志》2018年第5期516-519,522,共5页Medical Science Journal of Central South China

摘　　要：为了分析宫颈病变患者TWIST与上皮型钙黏附素(E-Cadherin)的表达水平与宫颈癌发生发展相关性。收集宫颈癌标本74例、同期完整CIN标本35例及正常宫颈组织22例,免疫组化染色法检测TWIST与E-Cadherin的表达水平。结果显示,与正常宫颈、CIN组织相比,TWIST在宫颈癌组织中的阳性表达率增高,E-Cadherin表达降低,这种表达差异与宫颈癌间质浸润深度和淋巴结转移有关(P<0.05),且TWIST与E-Cadherin在宫颈癌组织中表达水平呈负相关(r=-0.511,P<0.05)。结果提示TWIST表达增加与E-Cadherin表达降低可能与宫颈癌的发生发展及肿瘤细胞浸润转移密切相关。In order to analyze the expression levels of TWIST and E-Cadherin in patients with cervical lesions,and their correlation in the development and progression of cervical cancer. 74 cases of patients with complete cervical cancer, 35 cases of complete CIN specimens and 22 cases of normal cervical tissues were collected. Immunohistochemical staining was used to detect the expressions of TWIST and E-Cadherin. Results showed that compared to normal cervical tissues and CIN tissues, the expressions of TWIST in cervical cancer tissues was higher, but E-Cadherin was decreased, which was related to the depth of interstitial infiltration of cervical carcinoma and lymph node metastasis （ P 〈0.05）,while the expression level of TWIST in cervical cancer tissues was negatively correlated with the expression level of E-Cadherin （ r=-0.511, P 〈0.05）. The results suggesting that increase of TWIST expression and the decrease of E-Cadherin expression level may be related to the development and progression of cervical cancer and the invasion metastasis of tumor cells.

关 键 词：宫颈病变 TWIST 上皮型钙黏附素 相关性 

分 类 号：R711[医药卫生—妇产科学]