阿魏酸钠+参麦注射液方案用于急性心肌梗死辅助治疗的临床价值研究  

The clinical value of sodium ferulate+ Shenmai injection in the adjuvant treatment of acute myocardial infarction

作　　者：谭璐[1] 汪曲[1] 杨峰[2] 周汉云[2] 马可忠[2] 刘娟[2] TAN Lu;WANG Qu;YANG Feng;ZHOU Han-yun;MA Ke-zhong;LIU Juan(Department of Pharmacy,Huanghang Central hospital in Hubei Province,Huanggang Hubei Province,438000,China;Department of Cardiovascular Medicine,Xiangyang Central Hospital in Hubei Province（the Affiliated Hospital of Hubei University of Arts and Science）,Xiangyang,Hubei Province,441021,China)

机构地区：[1]湖北省黄冈市中心医院药剂科,湖北黄冈438000 [2]襄阳市中心医院(湖北文理学院附属医院)心血管内科,湖北襄阳441021

出　　处：《海南医学院学报》2018年第17期1547-1550,1554,共5页Journal of Hainan Medical University

基　　金：湖北省自然科学基金青年项目(2016CFB344)~~

摘　　要：目的:探讨阿魏酸钠+参麦注射液方案用于急性心肌梗死(AMI)辅助治疗的临床价值。方法:2014年12月～2017年12月间在本院接受治疗的AMI患者119例,回顾治疗方案并将其分为接受常规西医加参麦注射液治疗的对照组60例、接受常规西医+阿魏酸钠+参麦注射液方案治疗的阿魏酸钠组59例。对比两组治疗前、治疗2周后血清中心肌损伤标志物、炎症介质、心室重塑相关指标含量的差异。结果:治疗前,两组血清中心肌损伤标志物、炎症介质、心室重塑相关指标含量的差异不显著。治疗2周后,阿魏酸钠组血清中心肌损伤标志物GMP-140、cTnT、MYO、NT-proBNP、H-FABP的含量低于对照组;血清中炎症介质MCP-1、IL-18、hs-CRP的含量低于对照组;血清中心室重塑相关指标GDF-15、MMP-10、CgA的含量低于对照组,IGF-1的含量高于对照组。结论:AMI患者在西医基础上接受阿魏酸钠+参麦注射液方案治疗,可有效保护患者心肌功能并抑制全身炎症反应以及心室重塑。Objective：To explore the clinical value of sodium ferulate＋ Shenmai injection in the adjuvant treatment of acute myocardial infarction（AMI）.Methods：A total of 119 patients with AMI who were treated in our hospital between December 2014 and December 2017 were reviewed and divided into the control group（n=60）who received conventional western medicine＋ Shenmai injection therapy and the sodium ferulate group（n=59）who received conventional western medicine＋sodium ferulate＋ Shenmai injection therapy.The differences in serum levels of myocardial injury markers,inflammatory mediators and ventricular remodeling-related indexes were compared between the two groups before treatment and after 2 weeks of treatment.Results：Before treatment,serum levels of myocardial injury markers,inflammatory mediators and ventricular remodeling-related indexes were not significantly different between the two groups.After 2 weeks of treatment,serum myocardial injury markers GMP-140,cTnT,MYO,NT-proBNP and H-FABP levels of sodium ferulate group were lower than those of control group;serum inflammatory mediators MCP-1,IL-18 and hs-CRP levels were lower than those of control group;serum ventricular remodeling-related indexes GDF-15,MMP-10 and CgA levels were lower than those of control group whereas IGF-1 level was higher than that of control group.Conclusion：Western medicine combined with sodium ferulate＋ Shenmai injection therapy can effectively protect the myocardial function and inhibit the systemic inflammatory response and ventricular remodeling in patients with AMI.

关 键 词：急性心肌梗死 阿魏酸钠 参麦注射液 

分 类 号：R542.22[医药卫生—心血管疾病]