表皮生长因子联合美宝创疡贴在修复指腹皮肤软组织缺损中的疗效观察  

Clinical observation of recombinant human epidermal growth factor combined with Mebo wound and ulcer dressing in the repair of soft tissue defect of finger pulp

作　　者：侯国玲[1] 李明[1] 高栋梁[1] HOU Guo-ling;LI Ming;GAO Dong-liang(Affiliated Hospital of Yan＇an University,Yan＇an 716000,China)

机构地区：[1]延安大学附属医院烧伤整形手外科,陕西延安716000

出　　处：《延安大学学报（医学科学版）》2018年第3期39-41,共3页Journal of Yan'an University:Medical Science Edition

摘　　要：目的评价在指腹皮肤软组织缺损修复中使用表皮生长因子联合美宝创疡贴的应用价值。方法收集延安大学附属医院烧伤整形手外科2016-02~2017-02期间不愿手术治疗的指腹皮肤软组织缺损(无肌腱及骨外露)患者64例,随机分为2组,对照组采用普通碘伏凡士林纱布换药治疗,观察组采用重组表皮生长因子联合创疡贴换药治疗,观察肉芽组织、表皮生长情况及创面愈合情况。结果观察组愈合率为100%,对照组愈合率为100%,差异无统计学意义(P> 0. 05)。观察组创面完全愈合时间(11. 31±3. 52) d短于对照组的(14. 23±. 3. 11) d,差异有统计学意义(P <0. 01)。结论在指腹皮肤软组织缺损创面应用表皮生长因子联合创疡贴应用价值较高,可促进创面愈合,临床疗效好,值得临床应用和推广。Objective To evaluate the clinical value of recombinant human epidermal growth factor for external use combined with Mebo wound and ulcer dressing in the repair of soft tissue defect of finger pulp. Methods A total of 64 patients with soft tissue defects （no tendon and bone exposure） who were unwilling to undergo surgery during the period from February 2016 to February 2017 were collected from the Department of Burn and Plastic Surgery, Yan＇an University Hospital. They were randomly divided into 2 groups. The control group was treated with ordinary iodophor Vaseline gauze. The observation group was treated with recombinant epidermal growth factor combined with wound dressing and dressing to observe the granulation tissue, epidermal growth and wound healing. Results The healing rate of the observation group was 100%, and the healing rate of the control group was 100%, the difference was not statistically significant （P〉0.05）. The complete healing time of the observation group （11.31＋3.52） d was shorter than that of the control group （14.23＋3.11） d, and the difference was statistically significant （P〈0.01）. Conclusion The application of recombinant human epidermal growth factor for external use combined with Mebo wound and ulcer dressing in the treatment of superficial soft tissue defect of the finger pulp is of high value. It can promote wound healing, and has good clinical efficacy. It is worthy of clinical application and promotion.

关 键 词：指腹皮肤软组织缺损 重组表皮生长因子 创疡贴 

分 类 号：R34[医药卫生—基础医学]