植入用缓释氟尿嘧啶在直肠癌患者中的安全性评价  

Safety of Fluorouracil Implants in Colorectal Cancer

作　　者：翟丹丹 ZHAI Dan-dan(The second hospital of Hefei,Hefei 230022,China)

机构地区：[1]安徽省合肥市第二人民医院,合肥230022

出　　处：《海峡药学》2018年第9期86-88,共3页Strait Pharmaceutical Journal

基　　金：2008年安徽省高校自然科学重点研究项目(项目编号:KJ2009A033);2009年安徽省卫生厅青年基金项目(项目编号:09B129)

摘　　要：目的观察直肠癌患者根治术中植入缓释氟尿嘧啶的安全性,探究缓释氟尿嘧啶植入剂治疗直肠癌患者中的临床价值。方法将40例直肠癌患者按治疗方法分为两组:术中植入缓释氟尿嘧啶20例(植入剂组),氟尿嘧啶全身化疗组20例(对照组)。观测直肠癌根治患者术前,术后的白细胞计数,红细胞计数数,肝肾功能指标。记录患者的住院天数。记录患者术后不良反应:有无腹痛,切口有无水肿,有无愈合延迟,有无组织液化,有无吻合口瘘。结果植入剂组和对照组组间无统计学差异(P> 0. 05),两组患者术后不良反应方面无显著性差异(P>0. 05),治疗前后两组患者的白细胞计数和谷丙转氨酶有统计学差异(P <0. 05),且治疗后高于治疗前。结论直肠癌患者术中植入缓释氟尿嘧啶疗效确切,使用安全,患者顺应性强,适合在临床上推广。OBJECTIVE To observe the safety of fluorouracil implants in colorectal cancer,and investigate clinical value of fluorouracil implants in colorectal cancer. METHODS A total of 40 cases with colorectal cancer were divided into two groups according to different therapies：implant group（n=20） and control group （n=20）.To measure the patients WBC,RBC and hepatorenal function of Pre-and post-operative.Observe if there are stomachache,incision edema,delayed union,organization liquefaction and anastomotic leakage. RESULTS The differences in stomachache,incision edema,delayed union,organization liquefaction,anastomotic leakage and RBC between two groups were not significantly（ P 〉0.05）.The level of WBC and glutamic-pyruvic transaminase,and creatinine were significantly increased after operation compared with before operation （ P 〈0.05）,but there was no significant difference between the two groups. CONCLUSION The method of implanting sustained-release fluorouracil for colorectal cancer was safe so it can be widely spreaded in clinic use.

关 键 词：5-氟尿嘧啶 植入剂 不良反应 安全性 

分 类 号：R969.4[医药卫生—药理学]