合并血脂异常的原发性高血压患者血脂水平与血压变异性的关系  

Relationship between blood lipid level and blood pressure variability in patients with primary hypertension complicated with dyslipidemia

作　　者：方士杰 张强[1] 杨丽红[2] 孙彩红[1] 徐晓婷 刘英[1] 刘方方 FANG Shi-jie;ZHANG Qiang;YANG Li-hong;SUN Cai-hong;XU Xiao-ting;LIU Ying;LIU Fang-fang(Department of Cardiology Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China;Department of Cardiac Function,Henan Provincial People＇s Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学第二附属医院心内科,河南郑州市450014 [2]河南省人民医院心功能科,郑州市450000

出　　处：《广西医学》2018年第17期1925-1928,共4页Guangxi Medical Journal

基　　金：河南省科技攻关项目(182102310509)

摘　　要：目的分析合并血脂异常的原发性高血压患者血脂水平与血压变异性的关系。方法回顾性分析200例原发性高血压病患者的临床资料,根据血脂水平将其分为单纯高血压组、血脂异常组各100例,行血脂检测及24 h动态血压监测,比较两组患者的血压变异性参数,分析血脂异常组患者血脂水平与血压变异性的相关性。结果血脂异常组动态血压参数及24 h收缩压变异系数(24h SBP-CV)、白天收缩压变异系数(d SBP-CV)、夜间收缩压变异系数(n SBP-CV)、夜间舒张压变异系数(n DBP-CV)均高于单纯高血压组(均P<0.05)。血脂异常组患者24h SBP-CV、d SBP-CV、n SBP-CV、n DBP-CV与TC、TG、LDL-C均呈正相关(均P<0.05),与HDL-C呈负相关(P<0.05)。结论合并血脂异常的原发性高血压患者BPV增加,其血脂水平越高血压变异性越大。Objective To analyze the relationship between blood lipid level and blood pressure variability（BPV） in the patients with primary hypertension complicated with dyslipidemia. Methods Clinical data of 200 patients with primary hypertension were retrospectively analyzed. The patients were divided into simple hypertension group（ n = 100） and dyslipidernia group（ n = 100） according to the blood lipid level. Detection of blood lipid and 24 h ambulatory blood pressure monitoring were performed in all patients. The parameters of BPV were compared between the two groups. The correlation of blood lipid level with BPV was analyzed in the patients of the dyslipideinia group. Results The parameters in the dyslipidemia group were all higher than those in the simple hypertension group（ all P 〈 0.05 ） ,including ambulatory blood pressure,24hSBP coefficient of variability（ 24hSBP-CV）, daytime SBP coefficient of variability （dSBP-CV）, nighttime SBP coefficient of variability（nSBP-CV） and nighttime DBP coefficient of variability（nDBP-CV）. In the dyslipidernia group,24hSBP-CV, dSBP-CV, nSBP-CV and nDBP-CV positively correlated with TC, TG and LDL-C （ all P 〈 0.05 ）, and negatively correlated with HDL-C （ P 〈 0.05 ）. Conclusion The primary hypertension patients complicated with dyslipidemia have an increased BPV, and the BPV is larger when the blood lipid level is higher.

关 键 词：原发性高血压 血脂 血压变异性 相关性 

分 类 号：R544.1[医药卫生—心血管疾病]