鸟氨酸脱羧酶抗酶抑制剂蛋白家族研究进展  

Research progress of the ornithine decarboxylase antizyme inhibitor family

作　　者：张钰宏 柴晓颖 刘森[1,2] ZHANG Yuhong;CHAI Xiaoyin;LIU Sen(Medical School of China Three Gorges University,Key Laboratory of Tumor Microenvironment and Immunotherapy,Yichang 443002,China;National ＂111＂ Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]三峡大学医学院,肿瘤微环境与免疫治疗湖北省重点实验室,宜昌443002 [2]湖北工业大学,国家细胞调控与分子药物"111"引智基地,武汉430068

出　　处：《生命的化学》2018年第4期577-581,共5页Chemistry of Life

基　　金：国家自然科学基金项目(31670768,81602743);湖北省教育厅科学技术研究计划重点项目(D20161204);湖北省青年英才开发计划

摘　　要：鸟氨酸脱羧酶抗酶抑制剂蛋白(ornithine decarboxylase antizyme inhibitors,AZIN)家族有两个成员:AZIN1和AZIN2。AZIN1是一种能够负反馈性调节多胺合成和运输的蛋白质,其参与细胞周期、中心体复制、DNA损伤修复等重要的生理过程,同时也与许多疾病息息相关。AZIN2在脑和睾丸中高表达,是囊泡运输的调节剂,能够调节哺乳动物细胞中的多胺摄取和细胞分泌活性。本文对该鸟氨酸脱羧酶抗酶抑制剂蛋白领域的最新研究进展做了简要综述,以期为相关研究提供参考。The ornithine decarboxylase antizyme inhibitors（AZIN） family has two members： ornithine decarboxylase antizyme inhibitor 1（AZIN1） and ornithine decarboxylase antizyme inhibitor 2（AZIN2）. AZIN1 is a protein that negatively regulates the synthesis and transport of polyamines. It is involved in important physiological processes such as cell cycle, centrosome replication, DNA damage repair, and is also closely related to many diseases. AZIN2 is highly expressed in the brain and testis and is a regulator of vesicle trafficking, which can regulate polyamine uptake and cell secretion activity in mammalian cells. In this paper, a brief review of the latest research progress in the field of ornithine decarboxylase antizyme inhibitory proteins was conducted, with a view to providing reference for related research.

关 键 词：多胺 鸟氨酸脱羧酶 鸟氨酸脱羧酶抗酶抑制蛋白 

分 类 号：Q51[生物学—生物化学]