单硝酸异山梨酯注射液联合血栓通注射液治疗冠心病心绞痛临床研究  

Clinical Study on Isosorbide Mononitrate Injection Combined with Xueshuantong Injection for Coronary Heart Disease with Angina Pectoris

作　　者：赵海军 ZHAO Haijun

机构地区：[1]渭源县人民医院心内科,甘肃渭源748200

出　　处：《新中医》2018年第9期37-40,共4页New Chinese Medicine

摘　　要：目的:研究单硝酸异山梨酯注射液与血栓通联合治疗冠心病心绞痛的临床效果。方法:选择106例冠心病心绞痛患者,按照随机数字表法分为对照组和治疗组,各53例。对照组给予常规治疗并加用单硝酸异山梨酯注射液,治疗组以对照组为基础加用血栓通治疗。观察并记录2组中医证候积分、血脂水平、心绞痛症状积分,并对其临床疗效进行比较。结果:治疗组总有效率为94.34%,明显高于对照组的7 9.25%,差异有统计学意义(P<0.0 5)。治疗前,2组血脂指标甘油三酯(TC)、胆固醇(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平无显著差异(P>0.05);2组中医证候胸闷胸痛、心悸、夜尿、腰膝酸软积分无显著差异(P>0.05)。治疗后,2组TC、TG、LDL水平显著降低,HDL水平显著升高,中医证候胸闷胸痛、心悸、夜尿、腰膝酸软积分均下降,差异均有统计学意义(P<0.05);与对照组比较,治疗组TC、TG、LDL水平较低,HDL水平较高,中医证候胸闷胸痛、心悸、夜尿、腰膝酸软积分较低,差异均有统计学意义(P<0.05)。治疗后,治疗组心绞痛症状评分躯体活动、发作频率、发作程度、治疗满意度、疾病认知、症状总分评分显著高于对照组,差异均有统计学意义(P<0.05)。结论:临床治疗冠心病心绞痛联合使用单硝酸异山梨酯注射液与血栓通治疗疗效优于单用单硝酸异山梨酯注射液,同时可显著改善中医证候,调节血脂,缓解心绞痛,建议在临床推广使用。Objective： To study the clinical effect of isosorbide mononitrate injection combined with Xueshuantong injection for coronary heart disease with angina pectoris. Methods： Selected 106 cases of patients with coronary heart disease with angina pectoris into the control group and the treatment group according to random number table method, 53 cases in each group. The control group was given routine treatment combined with isosorbide mononitrate injection, while the treatment group additionally received Xueshuantong injection based on the treatment of the control group. Observed and recorded scores of Chinese medicine syndromes,the blood lipid level in the two groups,symptoms scores of angina pectoris,and compared the clinical effect. Results：The total effective rate was 94.34% in the treatment group, which was obviously higher than that of 79.25% in the control group, the difference being significant（P〈0.05）. Before treatment, no significant difference was found in the comparisons of levels of serum lipids indexes including triglyceride（TG）, total cholesterol（TC）, high density lipoprotein cholesterol（HDL） and low density lipoprotein cholesterol（LDL） between the two groups（P〈0.05）; no significant difference was found in the comparisons of scores of Chinese medicine syndromes including chest distress and chest pain,palpitation,nocturia and soreness and weakness of waist and knees between the two groups（P〈0.05）. After treatment, levels of TC, TG and LDL in the two groups were significantly decreased when compared withthose before treatment,and HDL levels were significantly increased when compared with those before treatment,and scores of Chinese medicine syndromes including chest distress and chest pain,palpitation,nocturia and soreness and weakness of waist and knees were decreased when compared with those before treatment, differences being significant（P〈0.05）. Compared with those in the control group respectively, levels of TC, TG and LDL in the control group were lower,

关 键 词：冠心病 心绞痛 单硝酸异山梨酯 血栓通注射液 血脂 心绞痛症状评分 中医证候积分 

分 类 号：R541.4[医药卫生—心血管疾病]