五行音乐联合一贯煎加减治疗轻中度围绝经期焦虑症临床观察  

Clinical Observation on Five-element Music Combined with Modified Yiguanjian for Mild-to-moderate Anxiety During Perimenopause

作　　者：姜云 王红卫 王芸 徐金贵[2] JIANG Yun;WANG Hongwei;WANG Yun;XU Jingui

机构地区：[1]衢州市中医医院,浙江衢州324002 [2]衢州市人民医院,浙江衢州324000

出　　处：《新中医》2018年第9期123-126,共4页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2016ZA222)

摘　　要：目的:观察五行音乐联合一贯煎加减治疗围绝经期焦虑症患者的临床疗效。方法:将最终完成研究的轻中度围绝经期焦虑症患者75例,分为对照1组25例、对照2组20例和治疗组30例。对照1组予一贯煎治疗,对照2组予五行音乐治疗,治疗组予五行音乐联合一贯煎治疗。每天1次,1月为1疗程,3组均治疗2疗程。比较治疗前后汉密尔顿焦虑量表(HAMD)评分和Kupperman评分,检测3组治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)及抗苗勒氏管激素(AMH)水平。结果:治疗后,对照1组、治疗组HAMD和Kupperman评分均较治疗前降低(P<0.05),对照2组HAMD和Kupperman评分与治疗前比较无差异(P>0.05);治疗组HAMD和Kupperman评分较对照1组、对照2组降低更明显(P<0.05),对照1组HAMD和Kupperman评分较对照2组降低更明显(P<0.05)。治疗后,对照1组血清FSH水平较治疗前降低(P<0.05),较对照2组亦降低(P<0.05);对照1组血清LH、AMH水平与治疗前比较,差异无统计学意义(P>0.05),与对照2组比较,差异无统计学意义(P>0.05)。治疗后,对照2组血清FSH、LH、AMH水平与治疗前比较,差异无统计学意义(P>0.05)。治疗后,治疗组血清FSH、LH水平均较治疗前降低(P<0.05),较对照1组、对照2组血清FSH、LH水平亦降低(P<0.05);治疗组AMH水平与治疗前比较,差异无统计学意义(P>0.05),与对照1组、对照2组比较,差异无统计学意义(P>0.05)。治疗后,总有效率对照1组为64.0%,对照2组为20.0%,治疗组为86.6%,3组分别比较,差异均有统计学意义(P<0.05)。结论:中药一贯煎在治疗围绝经期焦虑症方面疗效明确,若联合五行音乐疗法,能更好的改善焦虑症状及其他躯体不适。Objective： To observe theclinical effect of five-element music combined with modified Yiguanjian for patients with anxiety during perimenopause. Methods：Divided 75 cases of patients completed in the final study with mild-to-moderate anxiety during perimenopause into the control group 1,the control group 2 and the treatment group,25,20 and 30 cases in each group respectively.The control group 1 was treated with Yiguanjian; the control group 2 received five-element music for treatment; the treatment group was given five-element music combined with Yiguanjian for treatment. The three groups were treated once a day, and the treatment lasted for two courses, one month being one course. Compared scores of Hamilton depression scale（HAMD） and Kupperman scores before and after treatment. Detected levels of follicle-stimulating hormone（FSH）,luteinizing hormone（LH） and anti-mullerian hormone（AMH） in serum before and after treatment. Results：After treatment,scores of HAMD and Kupperman in the control group 1 and the treatment group were decreased when compared with those before treatment（P〈0.05）. Compared scores of HAMD and Kupperman in the control group 2 before and after treatment, there were no significance in the differences（P〈0.05）. Scores of HAMD and Kuppermanin the treatment group were decreased more obviously than those in the control group 1 and group 2（P〈0.05）. Scores of HAMD and Kupperman in the control group 1 were decreased more obviously than those in the control group 2（P〈0.05）. After treatment,the FSH level in serum in the control group 1 was decreased when compared with that before treatment（P〈0.05）,and was decreased when compared with that in the control group 2（P〈0.05）. Compared levels of LH and AMH in the control group 1 before and after treatment,there were no significance in the differences（P〉0.05）. Compared levels of LH and AMH in the control group 1 with those in the control group 2,there were no significance in the differences（P〉0.05

关 键 词：围绝经期 焦虑症 一贯煎 五行音乐 汉密尔顿焦虑量表(HAMD) KUPPERMAN评分 性激素 抗苗勒管激素(AMH) 

分 类 号：R271.11[医药卫生—中医妇科学]