加味桂枝代粥汤合桃红四物汤加减治疗经络瘀阻型白癜风临床研究  

Clinical Study on Modified Guizhi Daizhou Tang and Modified Taohong Siwu Tang for Vitiligo of Stasis Obstructing Meridians and Collaterals Type

作　　者：陈刚[1] CHEN Gang

机构地区：[1]湖州市中医院,浙江湖州313000

出　　处：《新中医》2018年第9期143-146,共4页New Chinese Medicine

摘　　要：目的:观察加味桂枝代粥汤合桃红四物汤加减治疗经络瘀阻型白癜风的临床疗效。方法:选取经络瘀阻型白癜风患者64例,随机分为治疗组和对照组各32例。2组均在外用白驳酊的基础上,对照组予甘草锌颗粒治疗,治疗组在对照组基础上加用加味桂枝代粥汤合桃红四物汤加减治疗,2组疗程均为6月。比较2组治疗后1月、3月、6月的临床疗效、治疗前后皮损面积和色素评分,记录2组不良反应发生情况。结果:治疗1月、3月、6月后,总有效率治疗组分别为37.50%、75.00%、78.13%,对照组分别为15.63%、46.88%、53.13%;同一时间点2组临床疗效比较,差异均有统计学意义(P<0.05)。治疗后,2组皮损面积均较治疗前减少(P<0.05),治疗组皮损面积较对照组减少更明显(P<0.05);2组皮肤色素评分均较治疗前升高(P<0.05),治疗组皮肤色素评分较对照组升高更明显(P<0.05)。2组不良反应发生率均为9.38%,2组比较,差异无统计学意义(P>0.05)。结论:运用加味桂枝代粥汤合桃红四物汤加减内服联合白驳酊外用治疗经络瘀阻型白癜风疗效确切,可以有效减少白癜风皮损情况,加速皮肤中黑色素的恢复,治疗期间无明显不良反应。Objective：To observe the clinical effect of modified Guizhi Daizhou tang and modified Taohong Siwu tang for vitiligo of stasis obstructing meridians and collaterals type. Methods：Divided 64 cases of patients with vitiligo of stasis obstructing meridians and collaterals type into the treatment group and the control group randomly, 32 cases in each group. The two groups were treated with external application of Baibo tincture. The control group additionally received Licorzine granules for treatment, while the treatment group additionally received modified Guizhi Daizhou tang and modified Taohong Siwu tang based on the treatment of the control group.The two groups were treated for six months. Compared the clinical effect in the two groups after 1, 3 and 6 months of treatment,scores of the skin lesion area and skin pigment before and after treatment, and recorded the adverse reactions in the two groups.Results： After 1, 3 and 6 months of treatment, the total effective rate was 37.50%, 75.00% and 78.13% respectively in the treatment group, and 15.63%, 46.88% and 53.13% respectively in the control group, differences between the two groups at the same time point being significant（P〈0.05）. After treatment, the skin lesion area in the two groups was decreased when compared with that before treatment（P〈0.05）. The skin lesion area in the treatment group was decreased more obviously than that in the control group（P〈0.05）. Scores of skin pigment in the two groups were increased when compared with those before treatment（P〈0.05）. The score of skin pigment in the treatment group was increased more obviously than that in the control group（P〈0.05）. The incidences of adverse reactions were both 9.38% in the two groups, there being no significance in the difference（P〉0.05）. Conclusion：The therapy of the oral administration of modified Guizhi Daizhou tang and modified Taohong Siwu tang combined with external application of Baibo tincture has accurate therapeutic effect in treating vitiligo

关 键 词：白癜风 经络瘀阻 加味桂枝代粥汤 桃红四物汤 白驳酊 

分 类 号：R758.41[医药卫生—皮肤病学与性病学] R275.9[医药卫生—临床医学]