射干麻黄重楼汤加减对老年过敏性哮喘冬季发作患者血清Th1/Th2因子影响的研究  

Modified Shegan Mahuang Chonglou Tang Has Effect on Th1/Th2 Cytokines in Serum of Senile Patients with Allergic Asthma Attack in Winter

作　　者：罗登攀[1] 戴凌云[1] 何雪云[1] 曾洁[1] LUO Dengpan;DAI Lingyun;HE Xueyun;ZENG Jie

机构地区：[1]衢州市人民医院,浙江衢州324000

出　　处：《新中医》2018年第9期153-156,共4页New Chinese Medicine

摘　　要：目的:探讨射干麻黄重楼汤加减对老年过敏性哮喘冬季发作患者血清Th1/Th2因子的影响。方法:研究对象选取74例老年过敏性哮喘患者,均尘螨点刺结果阳性,随机分成2组各37例。均予氨茶碱、特布他林等常规治疗,对照组予粉尘螨滴剂舌下含服,研究组在上述基础上予中药射干麻黄重楼汤加减口服。检测治疗前后血清Th1/Th2因子、特异性SIgG4以及嗜酸性粒细胞阳离子蛋白(ECP),评估肺功能和日夜间过敏性哮喘症状评分,比较治疗效果及安全性。结果:与治疗前比较,2组治疗后血清IL-2、IFN-γ水平均升高(P<0.05),IL-4以及IgE水平均降低(P<0.05)。与对照组治疗后比较,研究组IL-2、IFN-γ水平均较高(P<0.05),IL-4以及IgE水平均较低(P<0.05)。与治疗前比较,2组血清户尘螨SIgG4及粉尘螨SIgG4水平均明显升高(P<0.05),ECP水平明显降低(P<0.05);与对照组治疗后比较,研究组户尘螨SIgG4及粉尘螨SIgG4水平均明显较高(P<0.05),ECP水平明显较低(P<0.05)。2组治疗后肺功能指标呼气峰流速(PEF)、1秒用力呼气量容积(FEV_1)以及FEV_1/FVC均升高(P<0.01);与对照组治疗后比较,研究组PEF、FEV_1以及FEV_1/FVC均显著较高(P<0.01)。与治疗前比较,2组日间、夜间过敏性哮喘评分均降低(P<0.01);与对照组比较,研究组日间、夜间过敏性哮喘评分均较低(P<0.01)。对照组总有效率为83.78%,研究组总有效率为91.89%,2组比较,差异有统计学意义(P<0.05)。结论:射干麻黄重楼汤加减治疗过敏性哮喘效果理想,且能调节血清Th1/Th2细胞因子平衡。Objective：To discuss the effect of modified Shegan Mahuang Chonglou tang on Th1/Th2 cytokines in serum of senile patients with allergic asthma attack in winter. Methods：Selected 74 cases of senile patients with allergic asthma who had positive results of skin prick test of dust mites, and divided them into two groups randomly, 37 cases in each group. Both groups were given the routine treatment with aminophylline and terbutaline,and the control group received the sublingual administration of dermatophagoides farinae drops,while the study group additionally received the oral administration of modified Shegan Mahuang Chonglou tang. Detected Th1/Th2 cytokines in serum,specific SIg G4 and eosinophil cationic protein（ECP） before and after treatment,evaluated the pulmonary functions and scores of allergic asthma symptoms during daytime and nighttime,and compared the clinical effect and safety. Results：Comparing with those before treatment,the levels of IL-2 and IFN-γ in both groups were increased（P〈0.05）,and the levels of IL-4 and Ig E were decreased（P〈0.05）. Comparing with those in the control group after treatment,the levels of IL-2 and IFN-γ in the study group were higher（P〈0.05）,and the levels of IL-4 and Ig E were lower（P〈0.05）. Comparing with those before treatment,the levels of SIg G4 in dermatophagoides pteronyssinus and dermatophagoides farinae in serum of both groups were significantly increased（P〈0.05）,and the levels of ECP were significantly decreased（P〈0.05）. Comparing with those in the control group after treatment, the levels of SIg G4 in dermatophagoides pteronyssinus and dermatophagoides farinae in serum of the study group were significantly higher（P〈0.05）,and the level of ECP was significantly lower（P〈0.05）. After treatment,the pulmonary function indexes including peakexpiratory flow（PEF）,forced expiratory volume in one second（FEV1） and FEV1/FVC in both groups were increased（P〈0.01）;comparing with those in the control group afte

关 键 词：过敏性哮喘 射干麻黄重楼汤 尘螨SIgG4 TH1 TH2 

分 类 号：R256.12[医药卫生—中医内科学]