铜绿假单胞菌注射液对H22小鼠移植瘤的辅助治疗效果  

The Efficacy of Pseudomonas Aeruginosa-mannose Sensitive Hemagglutinin on H22 Mice Transplanted Tumor

作　　者：饶子亮[1] 郑佳琳[1] 黄威[1] 王弋[1] 潘诗云 黄绮玲 邝少松[1] RAO Ziliang;ZHENG Jialin;HUANG Wei;WANG Yi;PAN Shiyun;HUANG Qiling;KUANG Shaosong(GuangDong Medical Laboratory Animal Center,Foshan 528248,China;Beijing Wanter Bio-Pharmaceutical,Beijing 100000,China)

机构地区：[1]广东省医学实验动物中心,佛山528248 [2]北京万特尔生物制药有限公司,北京100000

出　　处：《实验动物科学》2018年第4期40-44,共5页Laboratory Animal Science

基　　金：广东省科技计划项目(No.2016A030303027;No.2013B060300033)

摘　　要：目的研究铜绿假单胞菌注射液联合化疗对H22小鼠移植瘤的影响。方法采用H22细胞株,移植53只BALB/c小鼠皮下。取肿块大小相对均匀的48只小鼠随机分成6组:空白对照、铜绿假单胞菌组、联合顺铂组、联合阿霉素组、顺铂组、阿霉素组,8只/组。连续给药14 d。结果联合顺铂组、顺铂组的抑瘤率为49.2%、46.6%,联合阿霉素组、阿霉素组的抑瘤率为32.1%、19.8%。结论铜绿假单胞菌注射液对H22小鼠移植瘤的阿霉素化疗有一定的增强效果。Objective The efficacy of pseudomonas aeruginosa-mannose sensitive hemagglutinin on H22 mice transplanted tumor. Method H22 cells were implanted into the subcutaneously of 53 BALB/c mice. Forty eight mice were randomly divided into 6 groups. And set up Control group, Pseudomonas aeruginosa group, Combined cisplatin group, Combined adriamycin group, cisplatin group, adriamycin group, 8 mice/group. Continuous administration for 14 days. Result The tumor inhibition rate of combined cisplatin group and cisplatin group were 49.2% and 46.6% , and the tumor inhibition rate of adriamycin group and adriamycin group was about 32. 1% and 19.8%. Conclusion Pseudomonas Aeruginosa Injection can enhance the effect of adriamycin chemotherapy on H22 mice.

关 键 词：铜绿假单胞菌注射液 联合化疗 H22 

分 类 号：R965.1[医药卫生—药理学]