Discovery of multi-drug resistant,MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China  

作　　者：Sijia Ding Xiaohu Han Jun Li Weifan Gao Zeliang Chen Youjun Feng 

机构地区：[1]School of Stomatology, Zhejiang Chinese Medical University [2]Key Laboratory of Zoonotic of Liaoning Province, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University [3]College of Animal Sciences, Zhejiang University [4]College of Biotechnology and Bioengineering, Zhejiang University of Technology

出　　处：《Science Bulletin》2018年第16期1059-1066,共8页科学通报（英文版）

基　　金：supported by National Key R&D Program of China (2017YFD0500202,YF);National Key Basic Research Program of China (2016YFC1200100,YF);National Natural Science Foundation of China (31570027 & 81772142,YF)

摘　　要：An endemic multi-drug resistant ST117 E. coil isolate coproducing MCR-I and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Whole- genome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH- 5）. Among them, pHXHI and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-l-positive pathogens with pan-drug resistance proceeds via food chains.An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Wholegenome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains.

关 键 词：Lipid A MCR-1 Colistin resistance Transferable resistance to polymyxin Intrinsic colistin resistance Gut bacteria Microbiome 

分 类 号：S852.61[农业科学—基础兽医学]