组织工程支架材料对固有免疫反应的影响及调控效应  

Effects and regulatory mechanism of tissue engineering biomaterial scaffold on host innate immune response

作　　者：陈坤威 童亚林[2] 姚咏明[1] CHEN Kun-wei;TONG Ya-lin;YAO Yong-ming(Trauma Research Center,First Affiliated Hospital of Chinese PLA General Hospital,Beijing 100048,China;Department of Burns and Plastic Surgery,181 Hospital of Chinese PLA,Guilin,Guangxi 541002,China)

机构地区：[1]解放军总医院第一附属医院创伤外科研究中心,北京100048 [2]解放军第181医院烧伤整形中心,广西桂林541002

出　　处：《解放军医学杂志》2018年第8期698-703,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81730057);国家重点研发计(2017YFC1103302);漓江学者计划资助课题~~

摘　　要：组织工程生物材料支架作为促进机体组织损伤修复与再生的工具,在临床上已经使用多年。生物材料植入机体后不可避免地诱发宿主反应,过度的宿主反应会影响材料植入的成功率,直接影响损伤修复效果。如何调控宿主反应是组织修复过程中的关键问题。材料诱发的宿主反应主要由机体免疫系统参与调控,特别是固有免疫系统,同时固有免疫反应也是组织修复与再生过程中不可或缺的重要因素。近年来,生物材料对免疫功能的影响日益受到关注,许多资料表明组织工程材料参与固有免疫调控过程,材料成分,表面化学、理化特性,以及降解产物等均不同程度地影响固有免疫细胞的功能。本文对固有免疫在组织修复中的作用以及组织工程支架材料特性对固有免疫反应的影响作一综述。Tissue engineering biomaterial scaffold, as a tool, has been used clinically for many years to promote wound healing and tissue repair. Biomaterial implantation may unavoidably induce host response, and excessive host response can impact the success rate of implantation, and directly affect the outcome of the healing process. Therefore, reasonable modulation of host response during tissue healing process is crucial. The host response triggered by biomaterials is mainly regulated by the immune system, especially the innate immunity. Meanwhile, the innate immunity is an integral key factor in tissue repair and regeneration. In recent years, the impact of biomaterials on immune function is attracting more and more attention. Lots of studies have shown that tissue engineering biomaterials have been involved in innate immune regulation, and the material ingredients, surface chemistry, physicochemical properties, as well as the degradation products exert marked influence on the function of innate immune cells with different extents. This review is to brief our understanding concerning how the characteristics of tissue engineering scaffolds affect the innate immune system and the potential effect of innate immunity on tissue repair, which might be of great significance to seek a novel way for designing advanced immunomodulatory tissue engineering scaffolds.

关 键 词：组织工程 生物材料支架 生物材料特性 固有免疫 组织修复与再生 

分 类 号：R64[医药卫生—外科学] Q81[医药卫生—临床医学]