羟考酮自控静脉镇痛对腹腔镜胃癌根治患者术后恢复质量的影响  

Effect of Oxycodone on postoperative recovery quality of patients with laparoscopic radical gastrectomy

作　　者：李乐 赵博 卢锡华 LI Le;ZHAO Bo;LU Xi-hua(Department of Anesthesiology,Tumor Hospital Affiliated to Zhengzhou University,Zhengzhou 450008,China)

机构地区：[1]郑州大学附属肿瘤医院麻醉科,郑州450008

出　　处：《医药论坛杂志》2018年第7期21-23,28,共4页Journal of Medical Forum

基　　金：河南省高等学校重点科研项目计划(15A320076)

摘　　要：目的探讨羟考酮自控静脉镇痛对腹腔镜胃癌根治患者术后恢复质量的影响。方法选择拟行腹腔镜胃癌根治术的患者80例,采用随机数字表法将其分为2组(n=40):羟考酮组(O组)和舒芬太尼组(S组)。术后镇痛采用PCIA,舒芬太尼组:静脉泵含舒芬太尼(2μg/kg)和托烷斯琼(4.48 mg);羟考酮组:静脉泵含羟考酮(1 mg/kg)和托烷斯琼(4.48 mg);采用QoR-40量表评估术后恢复质量,VAS评分评估术后镇痛效果,Ramsay评分评估术后镇静效果,记录两组患者术后不良反应的发生情况。结果术后24 h羟考酮组患者QoR-40总评分、身体舒适度评分、情感状态评分及疼痛评分均高于舒芬太尼组,差异有统计学意义(P<0.05);术后48 h羟考酮组患者QoR-40总评分、身体舒适度及疼痛评分高于舒芬太尼组,差异有统计学意义(P<0.05);结论与舒芬太尼相比,羟考酮自控静脉镇痛更加有利于腹腔镜胃癌根治术患者的术后恢复。Objective To obeserve the effect of oxycodone on the postoperative recovery quality of patients with laparoscopic radical gastrectomy. Methods Eighty patients scheduled for elective laparoscopic radical resection of stomach cancer were divided into two groups（ n = 40 each）,according to the random number table： Oxycodone group（ Ogroup）and sufentanil group（ S group）. Postoperative analgesia using PCIA,group O（ oxycodone 1 mg/kg）,group S（ sufentanil 2 μg/kg）. Tropisetron 4. 48 mg was added to each group. After surgery,QoR-40 scores,pain scores,side effects were compared among groups. Results The total score,emotional status score,pain score and physical comfort score of QoR-40 in group O were higher than those in group S at 24 h after surgery（ P〈 0. 05）,The total score,pain score and physical comfort score of QoR-40 in group O were higher than those in group S at 48 h after surgery（ P〈 0. 05）. Conclusion Oxycodone PCIA may be more effective than sufentanil PCIA to rapid recovery of patients undergoing laparoscopic radical gastrectomy.

关 键 词：羟考酮 舒芬太尼 快速康复 自控静脉镇痛 

分 类 号：R614[医药卫生—麻醉学]