低频电针对不同月龄增龄性大鼠骨骼肌TGF-β/Smad信号通路的影响  

Effects of Low Frequency Electric Acupuncture on Different Months of Age-Related Rat Skeletal Muscle by TGF-β/Smad Signaling Pathway

作　　者：虎力[1] 温佩彤 张伟波[1] 高原[1] 寿崟 王晓南[2] 徐平[1] HU Li;WEN Peitong;ZHANG Weibo;GAO Yuan;SHOU Yin;WANG Xiaonan;XU Ping(Acumox ＆ Tuina College of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Medicine of Emory University,Atlanta,GA 30322)

机构地区：[1]上海中医药大学针灸推拿学院,上海201203 [2]美国埃默里大学医学院,亚特兰大30322

出　　处：《中华中医药学刊》2018年第9期2064-2067,I0001,I0002,共6页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81403470);国家自然科学基金面上项目(81373755)

摘　　要：采用2 Hz电针分别对18、20和22月龄大鼠肾俞和足三里进行干预,探讨电针对TGF-β/Smad信号通路的作用,为延缓增龄所致的骨骼肌萎缩提供依据。认为电针干预能够减缓增龄性骨骼肌萎缩的进程,其机制可能与电针干预促进骨骼肌再生和/或后期降低骨骼肌的纤维化有关。Electroacupuncture by 2 Hz was used respectively for 18 months,20 months and 22 months of rats in this study. The effects of electroacupuncture on the TGF-β/Smad signaling pathway were explored to provide the basis for attenuating age-related skeletal muscle atrophy. We hold that electric acupuncture could attenuate aging-related rat skeletal muscle atrophy by promoting muscle regeneration and/or reducing skeletal muscle fibrosis in the later stage.

关 键 词：骨骼肌萎缩 增龄 骨骼肌卫星细胞 TGF-β/Smad 

分 类 号：R245.97[医药卫生—针灸推拿学]