中国类风湿关节炎患者报告的临床结局量表优化研究  

Study on Optimization of Chinese RA Patient-reported Outcome Scale

作　　者：韩曼[1] 巩勋[1] 唐晓颇[1] 刘宏潇[1] 刘健[2] 何东仪 张俊莉 李振彬[5] 黄清春[6] 王新昌 吴庆军[8] 方勇飞[9] 汪悦[10] 陈适[11] 蒋红[12] 高明利[13] 刘维[14] 刘英[15] 李泽光[16] 赵钟文[17] 王成武[18] 刘维超 王海东[20] 娄玉钤 孟庆良[22] 阮崇杰 谢雁鸣[24] 姜泉[1] HAN Man;GONG Xun;TANG Xiaopo;LIU Hongxiao;LIU Jian;HE Dongyi;ZHANG Junli;LI Zhenbin;HUANG Qingchun;WANG Xinchang;WU Qingjun;FANG Yongfei;WANG Yue;CHEN Shi;JIANG Hong;GAO Mingli;LIU Wei;LIU Ying;LI Zeguang;ZHAO Zhongwen;WANG Chengwu;LIU Weichao;WANG Haidong;LOU Yuqian;MENG Qingliang;RUAN Chongjie;XIE Yanming;JIANG Quan(Rheumatology Department,Guang＇anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,Anhui,China;Institute of Arthritis Research,Shanghai Academy of Chinese Medical Sciences,Guanghua Integrative Medicine Hospital,Shanghai 200052,China;Rheumatology Department,The Fifth Hospital of Xi＇an City,Xi＇an 710082,Shaanxi,China;Rheumatology Department,Bethune international peace hospital,Shijiazhuang 050082,Hebei,China;Rheumatology Department,Guangzhou Provincial Hospital of Traditional Chinese Medicine,Guangzhou 518021,Guangdong,China;Rheumatology Department,The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310004,China;Rheumatology Department,Peking Union Medical College Hospital,Beijing 100032,China;Rheumatology Department,Southwest Hospital,Third Military Medical University,Chongqing 400038,China;Jiangsu Provincial Hospital of Traditional Chinese Medicine,Nanjing 210029,Jiangsu,China;Rheumatology Department,Peking University People＇s Hospital,Beijing 100044,China;Rheumatology Department,The Ninth People＇s Hospital of Chongqing City,Chongqing 400700,China;Rheumatology Department,The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China;Rheumatology Department,The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300192,China;Rheumatology Department,The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,Shandong,China;Rheumatology Department,The First Affiliated Hospital of Heihingjiang University of Traditional Chinese Med

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]安徽中医药大学第一附属医院,安徽合肥230031 [3]上海市光华中西医结合医院,上海200052 [4]西安市第五医院,陕西西安710082 [5]白求恩国际和平医院,河北石家庄050082 [6]广东省中医院,广东广州518021 [7]浙江中医药大学附属第二医院,浙江杭州310005 [8]北京协和医院,北京100032 [9]中国人民解放军第三军医大学第一附属医院,重庆400038 [10]江苏省中医院,江苏南京210029 [11]北京大学人民医院,北京100044 [12]重庆市第九人民医院,重庆400700 [13]辽宁中医药大学附属第一医院,辽宁沈阳110032 [14]天津中医药大学第一附属医院,天津300192 [15]山东中医药大学附属医院,山东济南250011 [16]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [17]福建省第二人民医院,福建福州350003 [18]长春中医药大学第一附属医院,吉林长春130021 [19]云南省中医院,云南昆明650021 [20]甘肃省中医院,甘肃兰州730050 [21]河南风湿病医院,河南郑州450045 [22]河南省中医院,河南郑州450000 [23]武汉市中医院,湖北武汉430014 [24]中国中医科学院广安门医院临床评价中心,北京100053

出　　处：《中华中医药学刊》2018年第9期2116-2120,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家“十二五”科技支撑计划项目(2013BAI02B06)

摘　　要：目的：优化并修订＂基于中国人报告的类风湿关节炎患者临床结局（PRO）量表＂。方法：采用描述性研究,通过开展全国范围内多中心横断面调查进行原PRO量表应用评估,运用描述性分析、克朗巴赫系数法、因子分析法、多重线性回归等统计学方法进行条目优化、权重分配、评分方法、活动分级等优化量表。结果：共纳入来自全国19个省市23家医疗机构的1868例患者进行量表应用评估,通过数据分析将原条目进行删减、合并,拟合PRO总分与各条目的线性回归模型,得到修订后PRO总分的计算公式,并进行初步的活动度分为4个等级。优化后的PRO量表总体Cronbachα值为0.756,折半信度为0.733,共提取3个公因子,累计贡献率达53.199%。结论：优化后的中国类风湿关节炎患者报告的临床结局量表较原量表更加简洁、实用性及操作性更强,有待于进一临床推广应用和完善。Objective： To optimize and revise the＂Chinese RA patient-reported outcome scale＂. Method： A nationwide cross-sectional study was carried out to evaluate the scale by descriptive research method. Several statistical methods such as descriptive analysis,Cronbachα,factor analysis and multiple linear regression were adopted to optimize the items,assign weights,calculate the score and classify the activity. Result： A total of 1868 patients from 23 hospitals of 19 cities were investigated to evaluate the scale. The original items were cut and combined and the linear regression model was fitted to get the weight assignment. And then the final computational formula and the activity classification was obtained. The Cronbach α of the revised scale was 0. 756 and the split-half reliability coefficient was 0. 733. Three main common factors were extracted and the accumulating contribution rate was 53. 199%. Conclusion： The optimized scale was more concise and practical with more operability. But it remains to be perfected and needs more popularized application in clinics.

关 键 词：类风湿关节炎 患者报告的临床结局 量表优化 

分 类 号：R593.22[医药卫生—内科学]