何氏补肾促排卵汤联合肌注绒毛膜促性腺激素对未破裂卵泡黄素化综合征妊娠率、促排卵率及激素水平的影响  

Influence on Pregnancy Rate,Promoting Ovulation Rate and Hormone Levelsfor Treating Luteinized Unruptured Follicle Synodrome Patients with HE’s Bushen Cupailuan Decoction and HCG by Intramuscular Injection

作　　者：黄月颖[1] HUANG Yueying(TCM Gynecology Department,Ningbo Women and Children Hospital,Ningbo315012,Zhejiang,China)

机构地区：[1]宁波市妇女儿童医院中医妇科

出　　处：《中华中医药学刊》2018年第9期2258-2260,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技适宜技术推广项目(2017ZT005)

摘　　要：目的：探讨何氏补肾促排卵汤联合肌注绒毛膜促性腺激素（HCG）治疗未破裂卵泡黄素化综合征（Luteinized unruptured follicle synodrome,LUFS）患者的临床效果,并探讨其对患者妊娠率、促排卵率及激素水平的影响。方法：未破裂卵泡黄素化综合征患者92例,按照随机数字表法分为对照组和观察组各46例。对照组患者单纯给予肌注HCG治疗,观察组患者则在此基础上加用何氏补肾促排卵汤内服,3个月经周期为疗程。对比两组患者治疗后的临床效果,计算治疗后的妊娠率、促排卵率,监测排卵期两组患者的优势卵泡直径、卵泡成熟时间、成熟卵泡数及成熟卵泡日子宫内膜厚度,治疗后于成熟卵泡日检测两组患者促黄体生成素（LH）、雌二醇（E2）、孕激素（P）等激素水平变化。结果：观察组的临床有效率84.8%高于对照组的56.3%,差异显著（P〈0.05）;观察组治疗期间的妊娠率和促排卵率分别为39.1%、62.3%,与对照组的19.6%、34.1%相比明显升高,差异显著（P〈0.05）;观察组患者的卵泡发育情况优于对照组,其优势卵泡直径与对照组相比更大,卵泡成熟时间相对较短,成熟卵泡数更多,成熟卵泡日子宫内膜更厚,差异显著（P〈0.05）;治疗后成熟卵泡日观察组患者的LH、E2、P水平较对照组明显升高,差异显著（P〈0.05）。结论：何氏补肾促排卵汤联合肌注绒毛膜促性腺激素（HCG）利于提高未破裂卵泡黄素化综合征患者的妊娠率,疗效肯定,这与二者协同用药可改善卵泡发育、促进排卵、调控激素水平密切相关。Objective： To investigate the clinical efficacy of treating luteinized unruptured follicle synodrome patients with HE＇s Bushen Cupailuan Decoction and HCG by intramuscular injectionand explore the influence on pregnancy rate,promoting the ovulation rate and hormone levels. Methods： Ninety-two luteinized unruptured follicle synodrome patients were randomly divided into a control group of 46 cases and an observation group of 46 cases. Patients in the control group were treated with HCG by intramuscular injection,while those in the observation group were treated with HE＇s Bushen Cupailuan Decoction on the basis,lasting for three menstrual cycles. The research was aimed at comparing the effectiveness,calculating the pregnancy rate and promoting the ovulation rate,monitoring the advantages of follicle diameter,follicle stimulating time,mature follicle number and endometrial thickness in the mature follicle day,and testing the levels of LH,E2 and P. Results： The efficiency in the observation group was 84. 8%,which was higher than the control group＇s56. 3% and the difference was significant（ P 〈0. 05）. The pregnancy rate and promoting the ovulation rate of the observation group were 39. 1% and 62. 3%,which were higher than the control group＇s 19. 6% and 34. 1% and the difference was significant（ P 〈0. 05）. The observation group＇s follicular development situation was better than that of the control group and the advantages of follicle diameter was bigger,the follicle stimulating time was shorter,the mature follicle number was more and the endometrial thickness in the mature follicle day was thicker than those of the control group. The difference was significant（ P 〈0. 05）. The levels of LH,E2 and P were higher than that of the control group and the difference was significant（ P〈 0. 05）. Conclusion： The therapy can signficantly improve the pregnancy rate,and it has good effect,which is closely related to the drug efficacy of improving follicular development,promoting the ovulation

关 键 词：未破裂卵泡黄素化综合征 何氏补肾促排卵汤 肌注绒毛膜促性腺激素 妊娠率 促排卵率 激素水平 

分 类 号：R588.6[医药卫生—内分泌]