二甲双胍与炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症的效果  

Effect of Metformin and Ethynylestradiol Cyproteronee in the treatment of polycystic ovary syndrome infertility

作　　者：肖静[1] 黄佳[1] 郭晨[1] 江如[1] XIAO Jing;HUANG Jia;GUO Chen;JIANG Ru(Department of Reproductive Health,Jiangxi Maternal and Child Health Hospital,Jiangxi Province,Nanchang 330006,China)

机构地区：[1]江西省妇幼保健院生殖健康科,江西南昌330006

出　　处：《中国当代医药》2018年第25期133-136,共4页China Modern Medicine

摘　　要：目的探讨二甲双胍与炔雌醇环丙孕酮治疗多囊卵巢综合征不孕症的效果。方法选取2015年3月~2016年2月我院收治的60例多囊卵巢综合征不孕症患者作为研究对象,根据奇偶方式将其分为对照组和研究组,每组各30例。对照组患者给予炔雌醇环丙孕酮单一药物治疗,研究组在炔雌醇环丙孕酮治疗的基础上行二甲双胍治疗,两组患者均予以3个月的治疗。比较两组患者的性激素水平[促卵泡激素(FSH)、促黄体生成素(LH)、垂体催乳素(PRL)、睾酮(T)、雌2醇(E2)、孕酮(P)]、代谢水平[胰岛素受体(IR)、空腹胰岛素(FINS)、空腹葡萄糖(FBS)]、术后排卵情况及不良反应发生情况。结果研究组患者的LH[(8.31±2.15)IU/L]、T[(1.32±0.38)nmol/L]、E2[(114.66±8.80)pmol/L]、IR[(1.66±0.54)]、FINS[(7.44±2.31)m IU/ml]均低于对照组[(11.34±2.39)IU/L、(1.94±0.48)nmol/L、(118.57±7.90)pmol/L、(2.60±0.57)、(12.00±2.69)m IU/ml],流产率(3.33%)低于对照组(20.00%),排卵率(73.33%)及妊娠率(43.33%)均高于对照组(53.33%、23.33%),差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较,差异无统计学意义(P>0.05)。结论对多囊卵巢综合征不孕症患者行二甲双胍、炔雌醇环丙酮治疗,效果显著。Objective To investigate the effect of Metformin and Ethynylestradiol Cyproterone in the treatment of polycystic ovary syndrome infertility. Methods A total of 60 cases of infertility patients with polycystic ovary syndrome from March 2015 to February 2016 treated in our hospital were selected as study subjects. They were divided into the control group and the study group according to the parity method, with 30 cases in each group. The control group was treated with Ethynylestradiol Cyproterone alone, and the study group was given Metformin on the basis of Ethynylestradiol Cyproterone. All patients were treated for 3 months. Sex hormone levels（follicle stimulating hormone [FSH],luteinizing hormone [LH], pituitary prolactin [PRL], testosterone [T], estradiol [E2], progesterone [P]）, metabolic levels（Insulin receptor [IR], fasting insulin [FINS], fasting glucose [FBS]）, postoperative ovulation status and adverse reactions were compared in two groups. Results The levels of LH（[8.31±2.15] IU/L）, T（[1.32±0.38] nmol/L）, E2（[114.66±8.80]pmol/L）, IR（1.66±0.54） and FINS（[7.44±2.31] m IU/ml） in the study group were lower than those in the control group（[11.34 ±2.39] IU/L, [1.94 ±0.48] nmol/L, [118.57 ±7.90] pmol/L, [2.60 ±0.57], [12.00 ±2.69] m IU/ml）, and abortion rate（3.33%） in the study group were lower than that in the control group（20.00%）, the ovulation rate（73.33%） and pregnancy rate（43.33%） in the study group were higher than those in the control group（53.33%, 23.33%）, and the differences were statistically significant（P〈0.05）. There was no significant difference in the incidence of adverse reactions between two groups（P〈0.05）. Conclusion The effect of Metformin and Ethynylestradiol Cyproterone in the treatment of infertility patients with polycystic ovary syndrome is significant.

关 键 词：多囊卵巢综合征不孕症 炔雌醇环丙酮 二甲双胍 激素水平 不良反应 

分 类 号：R711.75[医药卫生—妇产科学]